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dc.contributor.authorWallace, W Hamish B
dc.contributor.authorShalet, Stephen M
dc.contributor.authorHendry, Jolyon H
dc.contributor.authorMorris-Jones, P H
dc.contributor.authorGattamaneni, Rao
dc.date.accessioned2010-09-18T09:34:21Z
dc.date.available2010-09-18T09:34:21Z
dc.date.issued1989-11
dc.identifier.citationOvarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte. 1989, 62 (743):995-8 Br J Radiolen
dc.identifier.issn0007-1285
dc.identifier.pmid2510900
dc.identifier.doi10.1259/0007-1285-62-743-995
dc.identifier.urihttp://hdl.handle.net/10541/111386
dc.description.abstractOvarian function has been studied sequentially since 1975 in 19 patients treated in childhood for an intra-abdominal tumour with surgery and whole abdominal radiotherapy (total dose 30 Gy). Eleven patients received chemotherapeutic agents that are not known to cause gonadal dysfunction. All but one patient have developed ovarian failure with persistently elevated gonadotrophin levels (FSH and LH greater than 32 IU/litre) and low serum oestradiol values (less than 40 pmol/litre) before the age of 16 years. The majority (n = 12) did not progress beyond breast stage 1 without sex steroid replacement therapy. As the number of oocytes within the ovary declines exponentially by atresia from approximately 2,000,000 at birth to approximately 2000 at the menopause, we have been able to estimate that the LD50 for the human oocyte does not exceed 4 Gy.
dc.language.isoenen
dc.subjectAbdominal Canceren
dc.subject.meshAbdomen
dc.subject.meshAbdominal Neoplasms
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshLethal Dose 50
dc.subject.meshOocytes
dc.subject.meshOvarian Function Tests
dc.subject.meshOvary
dc.subject.meshRadiation Tolerance
dc.subject.meshRadiotherapy, High-Energy
dc.titleOvarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte.en
dc.typeArticleen
dc.identifier.eissn1748-880X
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester.en
dc.identifier.journalThe British Journal of Radiologyen
html.description.abstractOvarian function has been studied sequentially since 1975 in 19 patients treated in childhood for an intra-abdominal tumour with surgery and whole abdominal radiotherapy (total dose 30 Gy). Eleven patients received chemotherapeutic agents that are not known to cause gonadal dysfunction. All but one patient have developed ovarian failure with persistently elevated gonadotrophin levels (FSH and LH greater than 32 IU/litre) and low serum oestradiol values (less than 40 pmol/litre) before the age of 16 years. The majority (n = 12) did not progress beyond breast stage 1 without sex steroid replacement therapy. As the number of oocytes within the ovary declines exponentially by atresia from approximately 2,000,000 at birth to approximately 2000 at the menopause, we have been able to estimate that the LD50 for the human oocyte does not exceed 4 Gy.


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