Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte.
Affiliation
Department of Endocrinology, Christie Hospital, Manchester.Issue Date
1989-11
Metadata
Show full item recordAbstract
Ovarian function has been studied sequentially since 1975 in 19 patients treated in childhood for an intra-abdominal tumour with surgery and whole abdominal radiotherapy (total dose 30 Gy). Eleven patients received chemotherapeutic agents that are not known to cause gonadal dysfunction. All but one patient have developed ovarian failure with persistently elevated gonadotrophin levels (FSH and LH greater than 32 IU/litre) and low serum oestradiol values (less than 40 pmol/litre) before the age of 16 years. The majority (n = 12) did not progress beyond breast stage 1 without sex steroid replacement therapy. As the number of oocytes within the ovary declines exponentially by atresia from approximately 2,000,000 at birth to approximately 2000 at the menopause, we have been able to estimate that the LD50 for the human oocyte does not exceed 4 Gy.Citation
Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte. 1989, 62 (743):995-8 Br J RadiolJournal
The British Journal of RadiologyDOI
10.1259/0007-1285-62-743-995PubMed ID
2510900Type
ArticleLanguage
enISSN
0007-1285EISSN
1748-880Xae974a485f413a2113503eed53cd6c53
10.1259/0007-1285-62-743-995
Scopus Count
Related articles
- Ovarian failure following abdominal irradiation in childhood: natural history and prognosis.
- Authors: Wallace WH, Shalet SM, Crowne EC, Morris-Jones PH, Gattamaneni HR
- Issue date: 1989 Nov
- Predicting age of ovarian failure after radiation to a field that includes the ovaries.
- Authors: Wallace WH, Thomson AB, Saran F, Kelsey TW
- Issue date: 2005 Jul 1
- Ovarian failure in long-term survivors of childhood malignancy.
- Authors: Stillman RJ, Schinfeld JS, Schiff I, Gelber RD, Greenberger J, Larson M, Jaffe N, Li FP
- Issue date: 1981 Jan
- The radiosensitivity of the human oocyte.
- Authors: Wallace WH, Thomson AB, Kelsey TW
- Issue date: 2003 Jan
- The role of ionizing radiaton on ovulation rate and oocyte morphology in mouse.
- Authors: Sapmaz-Metin M, Kanter M, Uzal C
- Issue date: 2014 Mar