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    Methods to assess changes in the pattern of nuclear phosphoinositides.

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    Authors
    Divecha, Nullin
    Affiliation
    CRUK Inositide Laboratory, Paterson Institute for Cancer Research, Manchester, UK. ndivecha@picr.man.ac.uk
    Issue Date
    2010
    
    Metadata
    Show full item record
    Abstract
    Phosphatidylinositol (PtdIns) and its phosphorylated derivatives represent less than 5% of total membrane phospholipids in cells. Despite their low abundance, they form a dynamic signalling system that is regulated in response to a variety of extra and intra-cellular cues (Curr Opin Genet Dev 14:196-202, 2004). Phosphoinositides and the enzymes that synthesize them are found in many different sub-cellular compartments including the nuclear matrix, heterochromatin, and sites of active RNA splicing, suggesting that phosphoinositides may regulate specific functions within the nuclear compartment (Nat Rev Mol Cell Biol 4:349-360, 2003; Curr Top Microbiol Immunol 282:177-206, 2004; Cell Mol Life Sci 61:1143-1156, 2004). The existence of distinct sub-cellular pools has led to the challenging task of understanding how the different pools are regulated and how changes in the mass of lipids within the nucleus can modulate nuclear specific pathways. Here we describe methods to determine how enzymatic activities that modulate nuclear phosphoinositides are changed in response to extracellular stimuli.
    Citation
    Methods to assess changes in the pattern of nuclear phosphoinositides. 2010, 645:165-77 Methods Mol Biol
    Journal
    Methods in Molecular Biology
    URI
    http://hdl.handle.net/10541/111377
    DOI
    10.1007/978-1-60327-175-2_11
    PubMed ID
    20645188
    Type
    Article
    Language
    en
    ISSN
    1940-6029
    1064-3745
    ae974a485f413a2113503eed53cd6c53
    10.1007/978-1-60327-175-2_11
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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