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    Guidelines for the welfare and use of animals in cancer research.

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    Authors
    Workman, P
    Aboagye, E O
    Balkwill, F
    Balmain, A
    Bruder, Gail
    Chaplin, D J
    Double, J A
    Everitt, J
    Farningham, D A H
    Glennie, M J
    Kelland, L R
    Robinson, V
    Stratford, I J
    Tozer, G M
    Watson, S
    Wedge, S R
    Eccles, S A
    Show allShow less
    Affiliation
    Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK. Paul.Workman@icr.ac.uk
    Issue Date
    2010-05-25
    
    Metadata
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    Abstract
    Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
    Citation
    Guidelines for the welfare and use of animals in cancer research. 2010, 102 (11):1555-77 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/111376
    DOI
    10.1038/sj.bjc.6605642
    PubMed ID
    20502460
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    EISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6605642
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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