Guidelines for the welfare and use of animals in cancer research.
Authors
Workman, PAboagye, E O
Balkwill, F
Balmain, A
Bruder, Gail
Chaplin, D J
Double, J A
Everitt, J
Farningham, D A H
Glennie, M J
Kelland, L R
Robinson, V
Stratford, I J
Tozer, G M
Watson, S
Wedge, S R
Eccles, S A
Affiliation
Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK. Paul.Workman@icr.ac.ukIssue Date
2010-05-25
Metadata
Show full item recordAbstract
Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.Citation
Guidelines for the welfare and use of animals in cancer research. 2010, 102 (11):1555-77 Br J CancerJournal
British Journal of CancerDOI
10.1038/sj.bjc.6605642PubMed ID
20502460Type
ArticleLanguage
enISSN
0007-0920EISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6605642