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    Radiation and the genome: from risks to opportunities for therapeutic exploitation.

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    Authors
    Robson, T
    West, Catharine M L
    Affiliation
    School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. T.Robson@qub.ac.uk
    Issue Date
    2010-08
    
    Metadata
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    Abstract
    On 1 December 2009, the Radiation and Cancer Biology Committee of the British Institute of Radiology (BIR) held a one-day conference on the theme of radiation and the genome. Talks covered genomic instability (its importance for radiation-induced carcinogenesis and potential for exploitation in the development of novel chemoradiotherapy combinations) and the prospects of exploiting knowledge of the genome to understand how individual genetic variation can impact on a patient's likelihood of developing toxicity following radiotherapy. The meeting also provided an overview of stem cell biology and its relevance for radiotherapy in terms of both tumour (somatic) and normal tissue (germline) sensitivity to radiation. Moreover, the possibility of manipulating stem cells to reduce radiation-induced normal tissue damage was considered.
    Citation
    Radiation and the genome: from risks to opportunities for therapeutic exploitation. 2010, 83 (992):635-7 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/111177
    DOI
    10.1259/bjr/31552255
    PubMed ID
    20647508
    Type
    Article
    Language
    en
    ISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr/31552255
    Scopus Count
    Collections
    All Christie Publications
    Academic Department of Radiation Oncology - ADRO

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