Radiation and the genome: from risks to opportunities for therapeutic exploitation.
Affiliation
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. T.Robson@qub.ac.ukIssue Date
2010-08
Metadata
Show full item recordAbstract
On 1 December 2009, the Radiation and Cancer Biology Committee of the British Institute of Radiology (BIR) held a one-day conference on the theme of radiation and the genome. Talks covered genomic instability (its importance for radiation-induced carcinogenesis and potential for exploitation in the development of novel chemoradiotherapy combinations) and the prospects of exploiting knowledge of the genome to understand how individual genetic variation can impact on a patient's likelihood of developing toxicity following radiotherapy. The meeting also provided an overview of stem cell biology and its relevance for radiotherapy in terms of both tumour (somatic) and normal tissue (germline) sensitivity to radiation. Moreover, the possibility of manipulating stem cells to reduce radiation-induced normal tissue damage was considered.Citation
Radiation and the genome: from risks to opportunities for therapeutic exploitation. 2010, 83 (992):635-7 Br J RadiolJournal
The British Journal of RadiologyDOI
10.1259/bjr/31552255PubMed ID
20647508Type
ArticleLanguage
enISSN
1748-880Xae974a485f413a2113503eed53cd6c53
10.1259/bjr/31552255
Scopus Count
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