Radiation and the genome: from risks to opportunities for therapeutic exploitation.
AffiliationSchool of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. T.Robson@qub.ac.uk
MetadataShow full item record
AbstractOn 1 December 2009, the Radiation and Cancer Biology Committee of the British Institute of Radiology (BIR) held a one-day conference on the theme of radiation and the genome. Talks covered genomic instability (its importance for radiation-induced carcinogenesis and potential for exploitation in the development of novel chemoradiotherapy combinations) and the prospects of exploiting knowledge of the genome to understand how individual genetic variation can impact on a patient's likelihood of developing toxicity following radiotherapy. The meeting also provided an overview of stem cell biology and its relevance for radiotherapy in terms of both tumour (somatic) and normal tissue (germline) sensitivity to radiation. Moreover, the possibility of manipulating stem cells to reduce radiation-induced normal tissue damage was considered.
CitationRadiation and the genome: from risks to opportunities for therapeutic exploitation. 2010, 83 (992):635-7 Br J Radiol
JournalThe British Journal of Radiology
- Impact of UV Radiation on Genome Stability and Human Health.
- Authors: Roy S
- Issue date: 2017
- Ionizing radiation and genetic risks XIV. Potential research directions in the post-genome era based on knowledge of repair of radiation-induced DNA double-strand breaks in mammalian somatic cells and the origin of deletions associated with human genomic disorders.
- Authors: Sankaranarayanan K, Wassom JS
- Issue date: 2005 Oct 15
- Second cancers after radiotherapy: any evidence for radiation-induced genomic instability?
- Authors: Sigurdson AJ, Jones IM
- Issue date: 2003 Oct 13
- [Genomic instability in the offspring of irradiated parents: facts and interpretations].
- Authors: Dubrova IuE
- Issue date: 2006 Oct
- [Genetic instability as a driver for oncogenesis].
- Authors: Cazaux C
- Issue date: 2010 Nov