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    Use of multiple biological markers in radiotherapy-treated head and neck cancer.

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    Authors
    Silva, Priyamal
    Slevin, Nicholas J
    Sloan, Philip
    Valentine, Helen R
    Ryder, W David J
    Price, Patricia M
    West, Catharine M L
    Homer, Jarrod J
    Affiliation
    School of Cancer & Enabling Sciences, The University of Manchester, Manchester, UK.
    Issue Date
    2010-06
    
    Metadata
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    Abstract
    OBJECTIVE: Management of patients with head and neck squamous cell carcinoma is often based on clinical parameters, with little appreciation of the underlying tumour biology. Single biological marker studies fail to acknowledge the complexity of these tumours. Our aim was to define a profile of biological markers associated with outcome. DESIGN: This retrospective study involved consecutive patients with oropharyngeal squamous cell carcinoma treated with primary radiotherapy between 1996 and 2001. Pre-treatment biopsies were used to study the immunohistochemical expression of nine biological markers. Markers were chosen to reflect biologically relevant pathways. RESULTS: Following analysis of nine markers, a profile of two markers was derived (carbonic anhydrase 9 and major vault protein), the co-expression of which conferred a significantly poor probability of locoregional control. The prognostic effect of these biomarkers in combination was greater than their effect individually. CONCLUSION: Biomarker profiles can be established which highlight large differences in locoregional control. Identifying tumours that express both carbonic anhydrase 9 and major vault protein may facilitate patient selection for more aggressive treatment.
    Citation
    Use of multiple biological markers in radiotherapy-treated head and neck cancer. 2010, 124 (6):650-8 J Laryngol Otol
    Journal
    The Journal of Laryngology and Otology
    URI
    http://hdl.handle.net/10541/111126
    DOI
    10.1017/S0022215110000228
    PubMed ID
    20388242
    Type
    Article
    Language
    en
    ISSN
    1748-5460
    ae974a485f413a2113503eed53cd6c53
    10.1017/S0022215110000228
    Scopus Count
    Collections
    All Christie Publications
    Clinical Oncology
    Academic Department of Radiation Oncology - ADRO

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