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dc.contributor.authorKumar, Shant
dc.contributor.authorWest, David C
dc.contributor.authorPonting, Julie M
dc.contributor.authorGattamaneni, Rao
dc.date.accessioned2010-09-13T14:57:58Z
dc.date.available2010-09-13T14:57:58Z
dc.date.issued1989-09-15
dc.identifier.citationSera of children with renal tumours contain low-molecular-mass hyaluronic acid. 1989, 44 (3):445-8 Int J Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid2550372
dc.identifier.doi10.1002/ijc.2910440311
dc.identifier.urihttp://hdl.handle.net/10541/111083
dc.description.abstractThe molecular mass of hyaluronic acid (HA) rather than its serum concentration alone may be a hallmark of certain types of malignancy. A radiometric assay was used to measure HA levels in 35 children with renal tumours [33 Wilms' tumours and 2 bone metastasizing renal tumours of childhood (BMRTC)] and 20 normal siblings of children with cancer. The HA level in the sera of normal children was barely detectable and had a molecular mass of 1-5 x 10(5). In both Wilms' and BMRTC patients, very high levels of HA were found in preoperative serum samples; these fell dramatically following surgical excision of the tumours. A novel finding of our study was the presence of low-molecular-mass HA (similar to the angiogenic fragments of HA) in the sera of BMRTC patients. In contrast, high-molecular-mass HA (which is not angiogenic) was found in the sera of Wilms' patients (2 x 10(6) kDa). Following surgery in BMRTC patients, not only did serum HA levels fall to a value within normal ranges, but also the HA which remained was of high molecular mass.
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectKidney Canceren
dc.subjectBiological Tumour Markersen
dc.subjectWilms Tumouren
dc.subject.meshAdolescent
dc.subject.meshBone Neoplasms
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHyaluronic Acid
dc.subject.meshInfant
dc.subject.meshKidney Neoplasms
dc.subject.meshMale
dc.subject.meshMolecular Weight
dc.subject.meshTumor Markers, Biological
dc.subject.meshWilms Tumor
dc.titleSera of children with renal tumours contain low-molecular-mass hyaluronic acid.en
dc.typeArticleen
dc.identifier.eissn1097-0215
dc.contributor.departmentChristie Hospital, Manchester, UK.en
dc.identifier.journalInternational Journal of Canceren
html.description.abstractThe molecular mass of hyaluronic acid (HA) rather than its serum concentration alone may be a hallmark of certain types of malignancy. A radiometric assay was used to measure HA levels in 35 children with renal tumours [33 Wilms' tumours and 2 bone metastasizing renal tumours of childhood (BMRTC)] and 20 normal siblings of children with cancer. The HA level in the sera of normal children was barely detectable and had a molecular mass of 1-5 x 10(5). In both Wilms' and BMRTC patients, very high levels of HA were found in preoperative serum samples; these fell dramatically following surgical excision of the tumours. A novel finding of our study was the presence of low-molecular-mass HA (similar to the angiogenic fragments of HA) in the sera of BMRTC patients. In contrast, high-molecular-mass HA (which is not angiogenic) was found in the sera of Wilms' patients (2 x 10(6) kDa). Following surgery in BMRTC patients, not only did serum HA levels fall to a value within normal ranges, but also the HA which remained was of high molecular mass.


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