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    Radiation-induced hypopituitarism is dose-dependent.

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    Authors
    Littley, M D
    Shalet, Stephen M
    Beardwell, Colin G
    Robinson, E L
    Sutton, M L
    Affiliation
    Department of Endocrinology, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
    Issue Date
    1989-09
    
    Metadata
    Show full item record
    Abstract
    Radiation-induced hypopituitarism has been studied prospectively for up to 12 years in 251 adult patients treated for pituitary disease with external radiotherapy, ranging in dose from 20 Gy in eight fractions over 11 days to 45 Gy in 15 fractions over 21 days. Ten further patients were studied 2-4 years after whole-body irradiation for haematological malignancies using 12 Gy in six fractions over 3 days and seven patients were studied 3-11 years after whole-brain radiotherapy for a primary brain tumour (30 Gy, eight fractions, 11 days). Five years after treatment, patients who received 20 Gy had an incidence of TSH deficiency of 9% and in patients treated with 35-37 Gy, 40 Gy and 42-45 Gy, the incidence of TSH deficiency (22, 35 and 52% respectively) increased significantly (P less than 0.001) with increasing dose. A similar relationship was observed for both ACTH and gonadotrophin deficiencies when the 20 Gy group was compared to patients treated with 35-45 Gy (P less than 0.01 and P less than 0.05 respectively). Growth hormone deficiency was universal by 5 years over the dose range 35-45 Gy. In seven patients who were treated with 30 Gy in eight fractions over 11 days, deficiencies were observed at a similar frequency to the 40 Gy group (15 fractions, 21 days). No evidence of pituitary dysfunction was detected in the ten patients who received 12 Gy (six fractions, 3 days). Both total radiation dose and fractionation schedule may determine the incidence of pituitary hormone deficiencies. The dose below which deficiencies do not occur is probably irrelevant to therapeutic irradiation of pituitary and other intracranial neoplasms.
    Citation
    Radiation-induced hypopituitarism is dose-dependent. 1989, 31 (3):363-73 Clin Endocrinol
    Journal
    Clinical Endocrinology
    URI
    http://hdl.handle.net/10541/111082
    DOI
    10.1111/j.1365-2265.1989.tb01260.x
    PubMed ID
    2559824
    Type
    Article
    Language
    en
    ISSN
    0300-0664
    EISSN
    1532-8708
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2265.1989.tb01260.x
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