AffiliationDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, United Kingdom.
MetadataShow full item record
AbstractTransforming growth factor beta (TGF beta) suppresses the growth of differentiation inducible, murine IL-3-dependent multipotential cell lines but has no growth inhibitory effect upon an IL-3-independent (leukaemic) cell line arising from one of them, nor on IL-3-dependent cell lines that are unable to undergo differentiation. TGF beta inhibits in vitro colony formation by normal multipotential haemopoietic progenitor cells. Bipotential progenitors recruited by GM-CSF are, however, more resistant to the inhibitory effects of TGF beta, whereas progenitors recruited by the lineage restricted factor, M-CSF, are sensitive to the inhibitory effects. These data indicate that responsiveness to TGF beta is differentiation linked and studies with the cell lines suggest that response (or lack of response is not determined solely by levels of expression of TGF beta receptors. Furthermore, the effects of TGF beta 2 on haemopoietic progenitors are very similar to those induced by TGF beta.
CitationThe effects of TGF beta on haemopoietic cells. 1989, 1 (2):193-202 Growth Factors
- Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines.
- Authors: Jacobsen SE, Ruscetti FW, Dubois CM, Lee J, Boone TC, Keller JR
- Issue date: 1991 Apr 15
- Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.
- Authors: Keller JR, Jacobsen SE, Sill KT, Ellingsworth LR, Ruscetti FW
- Issue date: 1991 Aug 15
- Transforming growth factor beta selectively inhibits normal and leukemic human bone marrow cell growth in vitro.
- Authors: Sing GK, Keller JR, Ellingsworth LR, Ruscetti FW
- Issue date: 1988 Nov
- Transforming growth factor beta 1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines.
- Authors: Keller JR, Mantel C, Sing GK, Ellingsworth LR, Ruscetti SK, Ruscetti FW
- Issue date: 1988 Aug 1
- Effect of interleukin-4 on the growth of granulocyte-macrophage progenitor cells stimulated by hematopoietic growth factors.
- Authors: Sato T, Misago M, Tsukada J, Kikuchi M, Oda S, Chiba S, Eto S
- Issue date: 1990 Jun 1