Residual haemopoietic damage in the mouse after fractionated gamma-irradiation, down to 0.1 Gy per fraction.
Affiliation
Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, U.K.Issue Date
1989-01
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Residual damage in haemopoietic progenitor cell populations, spleen and granulocyte-macrophage colony-forming cells (CFU-S and GM-CFC) was detected in mice after 15 daily fractions where the dose per fraction was as low as 0.1 Gy. The injury was dose-dependent and after higher total fractionated doses of 7.5-10 Gy the CFU-S population recovered to about 50% of control between 2 and 12 months after irradiation. Residual damage was also detected in the stroma, in the form of reduced numbers of fibroblastoid colony-forming cells and of CFU-S in ossicles under the kidney capsule. The response to a second course of 15 fractions, given 3 weeks after the end of the first course, was similar and additive to the response to the first course in the short term. However, in the long term, recovery levels were similar after either one or two courses.Citation
Residual haemopoietic damage in the mouse after fractionated gamma-irradiation, down to 0.1 Gy per fraction. 1989, 14 (1):43-8 Radiother OncolJournal
Radiotherapy and OncologyDOI
10.1016/0167-8140(89)90007-8PubMed ID
2648480Type
ArticleLanguage
enISSN
0167-8140ae974a485f413a2113503eed53cd6c53
10.1016/0167-8140(89)90007-8
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