Response of human organs to single (or fractionated equivalent) doses of irradiation.
dc.contributor.author | Hendry, Jolyon H | |
dc.date.accessioned | 2010-09-10T14:13:46Z | |
dc.date.available | 2010-09-10T14:13:46Z | |
dc.date.issued | 1989-11 | |
dc.identifier.citation | Response of human organs to single (or fractionated equivalent) doses of irradiation. 1989, 56 (5):691-700 Int. J Radiat Biol | en |
dc.identifier.issn | 0955-3002 | |
dc.identifier.pmid | 2573665 | |
dc.identifier.doi | 10.1080/09553008914551921 | |
dc.identifier.uri | http://hdl.handle.net/10541/111005 | |
dc.description.abstract | Characteristics of the kinetics of radiation response of human tissues and organs are exemplified by effects in the testis and the ovary. Also, published dose-incidence curves for specified levels of injury in bone marrow, liver, bladder and lung are characterised in terms of single doses as well as single-dose equivalents calculated from fractionated doses using the alpha/beta equation. It is shown that these curves, analysed using a Poisson model, have slopes characterised by D0-equivalents ranging between 1.25 and 2.5 Gy. These values are higher or within the range of values reported in general for single-dose survival curves of human cells in primary culture (range of D0 values 0.7-1.8 Gy). This indicates that single-cell responses together with other complicating biological and statistical sources of heterogeneity under discussion, could form a basis for explaining the steepness of dose-incidence curves for organ injury after fractionated doses. With local organ irradiation, increase in the single-dose equivalent by 3-10 per cent would increase the complication rate from 5 per cent to 10 per cent. Higher dosage increases (by up to two times) apply to fractionated doses. | |
dc.language.iso | en | en |
dc.subject.mesh | Bone Marrow | |
dc.subject.mesh | Dose-Response Relationship, Radiation | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Liver | |
dc.subject.mesh | Lung | |
dc.subject.mesh | Male | |
dc.subject.mesh | Ovary | |
dc.subject.mesh | Tissue Survival | |
dc.subject.mesh | Urinary Bladder | |
dc.title | Response of human organs to single (or fractionated equivalent) doses of irradiation. | en |
dc.type | Article | en |
dc.contributor.department | Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K. | en |
dc.identifier.journal | International Journal of Radiation Biology | en |
html.description.abstract | Characteristics of the kinetics of radiation response of human tissues and organs are exemplified by effects in the testis and the ovary. Also, published dose-incidence curves for specified levels of injury in bone marrow, liver, bladder and lung are characterised in terms of single doses as well as single-dose equivalents calculated from fractionated doses using the alpha/beta equation. It is shown that these curves, analysed using a Poisson model, have slopes characterised by D0-equivalents ranging between 1.25 and 2.5 Gy. These values are higher or within the range of values reported in general for single-dose survival curves of human cells in primary culture (range of D0 values 0.7-1.8 Gy). This indicates that single-cell responses together with other complicating biological and statistical sources of heterogeneity under discussion, could form a basis for explaining the steepness of dose-incidence curves for organ injury after fractionated doses. With local organ irradiation, increase in the single-dose equivalent by 3-10 per cent would increase the complication rate from 5 per cent to 10 per cent. Higher dosage increases (by up to two times) apply to fractionated doses. |