Show simple item record

dc.contributor.authorHendry, Jolyon H
dc.date.accessioned2010-09-10T14:13:46Z
dc.date.available2010-09-10T14:13:46Z
dc.date.issued1989-11
dc.identifier.citationResponse of human organs to single (or fractionated equivalent) doses of irradiation. 1989, 56 (5):691-700 Int. J Radiat Biolen
dc.identifier.issn0955-3002
dc.identifier.pmid2573665
dc.identifier.doi10.1080/09553008914551921
dc.identifier.urihttp://hdl.handle.net/10541/111005
dc.description.abstractCharacteristics of the kinetics of radiation response of human tissues and organs are exemplified by effects in the testis and the ovary. Also, published dose-incidence curves for specified levels of injury in bone marrow, liver, bladder and lung are characterised in terms of single doses as well as single-dose equivalents calculated from fractionated doses using the alpha/beta equation. It is shown that these curves, analysed using a Poisson model, have slopes characterised by D0-equivalents ranging between 1.25 and 2.5 Gy. These values are higher or within the range of values reported in general for single-dose survival curves of human cells in primary culture (range of D0 values 0.7-1.8 Gy). This indicates that single-cell responses together with other complicating biological and statistical sources of heterogeneity under discussion, could form a basis for explaining the steepness of dose-incidence curves for organ injury after fractionated doses. With local organ irradiation, increase in the single-dose equivalent by 3-10 per cent would increase the complication rate from 5 per cent to 10 per cent. Higher dosage increases (by up to two times) apply to fractionated doses.
dc.language.isoenen
dc.subject.meshBone Marrow
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLiver
dc.subject.meshLung
dc.subject.meshMale
dc.subject.meshOvary
dc.subject.meshTissue Survival
dc.subject.meshUrinary Bladder
dc.titleResponse of human organs to single (or fractionated equivalent) doses of irradiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, U.K.en
dc.identifier.journalInternational Journal of Radiation Biologyen
html.description.abstractCharacteristics of the kinetics of radiation response of human tissues and organs are exemplified by effects in the testis and the ovary. Also, published dose-incidence curves for specified levels of injury in bone marrow, liver, bladder and lung are characterised in terms of single doses as well as single-dose equivalents calculated from fractionated doses using the alpha/beta equation. It is shown that these curves, analysed using a Poisson model, have slopes characterised by D0-equivalents ranging between 1.25 and 2.5 Gy. These values are higher or within the range of values reported in general for single-dose survival curves of human cells in primary culture (range of D0 values 0.7-1.8 Gy). This indicates that single-cell responses together with other complicating biological and statistical sources of heterogeneity under discussion, could form a basis for explaining the steepness of dose-incidence curves for organ injury after fractionated doses. With local organ irradiation, increase in the single-dose equivalent by 3-10 per cent would increase the complication rate from 5 per cent to 10 per cent. Higher dosage increases (by up to two times) apply to fractionated doses.


This item appears in the following Collection(s)

Show simple item record