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dc.contributor.authorBhavnani, M
dc.contributor.authorMorris Jones, P H
dc.contributor.authorTesta, Nydia G
dc.date.accessioned2010-09-10T13:42:45Z
dc.date.available2010-09-10T13:42:45Z
dc.date.issued1989-01
dc.identifier.citationChildren in long-term remission after treatment for acute lymphoblastic leukaemia show persisting haemopoietic injury in clonal and long-term cultures. 1989, 71 (1):37-41 Br. J. Haematol.en
dc.identifier.issn0007-1048
dc.identifier.pmid2917128
dc.identifier.doi10.1111/j.1365-2141.1989.tb06271.x
dc.identifier.urihttp://hdl.handle.net/10541/110999
dc.description.abstractTwenty children who were in unmaintained full haematological remission after treatment for acute lymphoblastic leukaemia (ALL) showed a significantly lower incidence of granulocyte-macrophage progenitor cells (GM-CFC) in the bone marrow compared to controls. This low incidence lasted for up to at least 3 years after the cessation of chemotherapy. There was no tendency to higher values with longer times after treatment, and the low incidence was not predictive of relapse. Long-term cultures from ALL bone marrows and from controls achieved similar levels of production of mature cells through the whole period of culture (6 weeks). However, cultures from patients' bone marrow had on average about 5 times lower numbers of GM-CFC, indicating that the level of mature cell production was achieved by a higher level of post-GM-CFC amplification than needed in the controls. This is taken to be due to compensatory mechanisms operative during stressed haemopoiesis which appears to be a long-lasting effect after current chemotherapy of ALL.
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshCells, Cultured
dc.subject.meshChild
dc.subject.meshColony-Forming Units Assay
dc.subject.meshFemale
dc.subject.meshHematopoiesis
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshTime Factors
dc.titleChildren in long-term remission after treatment for acute lymphoblastic leukaemia show persisting haemopoietic injury in clonal and long-term cultures.en
dc.typeArticleen
dc.contributor.departmentRoyal Manchester Children's Hospital.en
dc.identifier.journalBritish Journal of Haematologyen
html.description.abstractTwenty children who were in unmaintained full haematological remission after treatment for acute lymphoblastic leukaemia (ALL) showed a significantly lower incidence of granulocyte-macrophage progenitor cells (GM-CFC) in the bone marrow compared to controls. This low incidence lasted for up to at least 3 years after the cessation of chemotherapy. There was no tendency to higher values with longer times after treatment, and the low incidence was not predictive of relapse. Long-term cultures from ALL bone marrows and from controls achieved similar levels of production of mature cells through the whole period of culture (6 weeks). However, cultures from patients' bone marrow had on average about 5 times lower numbers of GM-CFC, indicating that the level of mature cell production was achieved by a higher level of post-GM-CFC amplification than needed in the controls. This is taken to be due to compensatory mechanisms operative during stressed haemopoiesis which appears to be a long-lasting effect after current chemotherapy of ALL.


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