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    Structure and regulation of the erythroid system at the level of progenitor cells.

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    Authors
    Testa, Nydia G
    Affiliation
    Department of Experimental Hematology, Paterson Institute for Cancer Research, Manchester, England.
    Issue Date
    1989
    
    Metadata
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    Abstract
    Considerable ground has been covered since the first clonal assays for hemopoietic cells were described. The possibility of studying populations of progenitor cells and the regulatory factors that influence them has already thrown considerable light on our understanding of the structure and physiology of the normal erythroid system and its alterations in disease. The relative importance of humoral and short-range factors and of possible cell-to-cell interactions in the regulation of proliferation and differentiation in the erythroid cell lineage is now being studied actively in several laboratories. The possibility of analyzing possible regulatory networks involving such highly reactive cells as lymphocytes and monocytes-macrophages in defined in vitro conditions now exists. As these studies are being extended to the diseased state, concepts related to alterations in regulatory mechanisms in syndromes with abnormal cell proliferation can be tested. Clinical applications in the treatment of patients with hematological disease are being contemplated. The usefulness of Epo for the treatment of the anemia of renal disease has been demonstrated already.
    Citation
    Structure and regulation of the erythroid system at the level of progenitor cells. 1989, 9 (1):17-35 Crit. Rev. Oncol. Hematol.
    Journal
    Critical Reviews in Oncology/Hematology
    URI
    http://hdl.handle.net/10541/110981
    DOI
    10.1016/S1040-8428(89)80013-7
    PubMed ID
    2649261
    Type
    Article
    Language
    en
    ISSN
    1040-8428
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1040-8428(89)80013-7
    Scopus Count
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    All Paterson Institute for Cancer Research

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