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dc.contributor.authorDias, P
dc.contributor.authorKumar, Patricia
dc.contributor.authorMarsden, Henry B
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorHeighway, Jim
dc.contributor.authorKumar, Shant
dc.date.accessioned2010-08-18T15:22:17Z
dc.date.available2010-08-18T15:22:17Z
dc.date.issued1990-04-15
dc.identifier.citationN-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. 1990, 45 (4):593-6 Int. J. Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid2323837
dc.identifier.doi10.1002/ijc.2910450403
dc.identifier.urihttp://hdl.handle.net/10541/109888
dc.description.abstractDNA from 13 (6 alveolar and 7 embryonal) childhood rhabdomyosarcomas (RMS) was examined to determine the incidence and prognostic relevance of N- and c-myc genes. Southern analysis showed 5- to 20-fold amplification of N-myc gene in 4 of 6 alveolar but in none of 7 embryonal RMS (p less than 0.04; Fisher's exact test). The number of children who died with multiple- and single-copy N-myc gene was 4/4 and 5/9 respectively (p greater than 0.05; Chi-squared test). There was no statistically significant correlation between N-myc amplification and age, gender, site, stage or survival time. There was no amplification or gross rearrangement of c-myc in any of the 13 RMS.
dc.language.isoenen
dc.subjectCancer DNAen
dc.subject.meshBlotting, Southern
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDNA, Neoplasm
dc.subject.meshFemale
dc.subject.meshGene Amplification
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshOncogenes
dc.subject.meshPrognosis
dc.subject.meshRhabdomyosarcoma
dc.titleN-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital and Holt Radium Institute, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Canceren
html.description.abstractDNA from 13 (6 alveolar and 7 embryonal) childhood rhabdomyosarcomas (RMS) was examined to determine the incidence and prognostic relevance of N- and c-myc genes. Southern analysis showed 5- to 20-fold amplification of N-myc gene in 4 of 6 alveolar but in none of 7 embryonal RMS (p less than 0.04; Fisher's exact test). The number of children who died with multiple- and single-copy N-myc gene was 4/4 and 5/9 respectively (p greater than 0.05; Chi-squared test). There was no statistically significant correlation between N-myc amplification and age, gender, site, stage or survival time. There was no amplification or gross rearrangement of c-myc in any of the 13 RMS.


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