Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia.
Affiliation
Department of Haematology, Christie Hospital, Manchester, United Kingdom.Issue Date
1990-10
Metadata
Show full item recordAbstract
Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.Citation
Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia. 1990, 35 (2):125-6 Am. J. Hematol.Journal
American Journal of HematologyDOI
10.1002/ajh.2830350212PubMed ID
1698019Type
ArticleLanguage
enISSN
0361-8609ae974a485f413a2113503eed53cd6c53
10.1002/ajh.2830350212
Scopus Count
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