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    Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia.

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    Authors
    Chang, James
    Craft, A W
    Reid, M M
    Coutinho, Lucia H
    Dexter, T Michael
    Affiliation
    Department of Haematology, Christie Hospital, Manchester, United Kingdom.
    Issue Date
    1990-10
    
    Metadata
    Show full item record
    Abstract
    Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.
    Citation
    Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia. 1990, 35 (2):125-6 Am. J. Hematol.
    Journal
    American Journal of Hematology
    URI
    http://hdl.handle.net/10541/109883
    DOI
    10.1002/ajh.2830350212
    PubMed ID
    1698019
    Type
    Article
    Language
    en
    ISSN
    0361-8609
    ae974a485f413a2113503eed53cd6c53
    10.1002/ajh.2830350212
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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