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dc.contributor.authorChang, James
dc.contributor.authorGeary, C
dc.contributor.authorTesta, Nydia G
dc.date.accessioned2010-08-18T15:04:54Z
dc.date.available2010-08-18T15:04:54Z
dc.date.issued1990-05
dc.identifier.citationLong-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time. 1990, 75 (1):68-72 Br. J. Haematol.en
dc.identifier.issn0007-1048
dc.identifier.pmid2375926
dc.identifier.doi10.1111/j.1365-2141.1990.tb02617.x
dc.identifier.urihttp://hdl.handle.net/10541/109881
dc.description.abstractThirteen patients with acute myeloid leukaemia (AML) who had been in unmaintained complete remission for at least 5 years following successful chemotherapy, were studied by marrow culture techniques regularly for periods of up to 5 years. In 10 patients, short-term clonal assay revealed the incidence of granulocyte-macrophage progenitor cells (GM-CFC) to be at the lower limit of the normal range; but three showed wide fluctuations in GM-CFC numbers. Moreover the generation of GM-CFC in long-term bone marrow culture (LTBMC) was impaired in eight of nine evaluable patients. These results suggest that, despite normal blood counts, impairment of haemopoiesis persists in patients who are long-term survivors of AML, and this does not improve with the passage of time.
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectAcute Myeloid Leukaemiaen
dc.subjectTumour Stem Cell Assayen
dc.subject.meshAdult
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBone Marrow
dc.subject.meshFemale
dc.subject.meshGranulocytes
dc.subject.meshHematopoiesis
dc.subject.meshHumans
dc.subject.meshLeukemia, Myeloid, Acute
dc.subject.meshMacrophages
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRemission Induction
dc.subject.meshTime Factors
dc.subject.meshTumor Stem Cell Assay
dc.titleLong-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Paterson Laboratory, Christie Hospital, Manchester.en
dc.identifier.journalBritish Journal of Haematologyen
html.description.abstractThirteen patients with acute myeloid leukaemia (AML) who had been in unmaintained complete remission for at least 5 years following successful chemotherapy, were studied by marrow culture techniques regularly for periods of up to 5 years. In 10 patients, short-term clonal assay revealed the incidence of granulocyte-macrophage progenitor cells (GM-CFC) to be at the lower limit of the normal range; but three showed wide fluctuations in GM-CFC numbers. Moreover the generation of GM-CFC in long-term bone marrow culture (LTBMC) was impaired in eight of nine evaluable patients. These results suggest that, despite normal blood counts, impairment of haemopoiesis persists in patients who are long-term survivors of AML, and this does not improve with the passage of time.


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