• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Long-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Chang, James
    Geary, C
    Testa, Nydia G
    Affiliation
    Department of Haematology, Paterson Laboratory, Christie Hospital, Manchester.
    Issue Date
    1990-05
    
    Metadata
    Show full item record
    Abstract
    Thirteen patients with acute myeloid leukaemia (AML) who had been in unmaintained complete remission for at least 5 years following successful chemotherapy, were studied by marrow culture techniques regularly for periods of up to 5 years. In 10 patients, short-term clonal assay revealed the incidence of granulocyte-macrophage progenitor cells (GM-CFC) to be at the lower limit of the normal range; but three showed wide fluctuations in GM-CFC numbers. Moreover the generation of GM-CFC in long-term bone marrow culture (LTBMC) was impaired in eight of nine evaluable patients. These results suggest that, despite normal blood counts, impairment of haemopoiesis persists in patients who are long-term survivors of AML, and this does not improve with the passage of time.
    Citation
    Long-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time. 1990, 75 (1):68-72 Br. J. Haematol.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/109881
    DOI
    10.1111/j.1365-2141.1990.tb02617.x
    PubMed ID
    2375926
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.1990.tb02617.x
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Effect of chemotherapy for acute myelogenous leukemia on hematopoietic and fibroblast marrow progenitors.
    • Authors: Carlo-Stella C, Tabilio A, Regazzi E, Garau D, La Tagliata R, Trasarti S, Andrizzi C, Vignetti M, Meloni G
    • Issue date: 1997 Sep
    • Changes in granulocyte-macrophage colony formation in relation to chemotherapy and clinical progress in acute myeloblastic leukaemia patients.
    • Authors: Miyao S, Tamura J, Sakuraya M, Murakami H, Naruse T
    • Issue date: 1998 Dec
    • Serial studies of bone marrow-derived fibroblastoid colony-forming cells and granulocyte/macrophage precursor cells in patients with acute leukemia.
    • Authors: Katsuno M, Hirata J, Kaneko S, Nishimura J, Motomura S, Ibayashi H
    • Issue date: 1986
    • Clonal remissions in acute myeloid leukaemia are commonly associated with features of trilineage myelodysplasia during remission.
    • Authors: Jowitt SN, Liu Yin JA, Saunders MJ, Lucas GS
    • Issue date: 1993 Dec
    • Growth of hemopoietic cells after incubation with VP 16-213.
    • Authors: Schulze E, Hofmann U, Woetzel M, Helbig W
    • Issue date: 1989
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.