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    Radiosensitivity testing of primary cervical carcinoma: evaluation of intra- and inter-tumour heterogeneity.

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    Authors
    Davidson, Susan E
    West, Catharine M L
    Roberts, Stephen A
    Hendry, Jolyon H
    Hunter, Robin D
    Affiliation
    Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, U.K.
    Issue Date
    1990-08
    
    Metadata
    Show full item record
    Abstract
    Biopsies from 89 patients with cervical carcinoma were studied using a clonogenic assay to obtain values for the surviving fraction at 2 Gy (SF2). Heterogeneity in intrinsic radiosensitivity was investigated by independently processing multiple biopsies from 18 tumors. No significant differences between intra-tumour SF2 values were demonstrated (p = 0.30). The results have shown that intra-tumour heterogeneity is not a limitation to radiosensitivity testing using the Courtenay-Mills assay. A wide range of values (0.13-0.97) for SF2 was obtained with a mean value of 0.47 +/- 0.18 (+/- 1 S.D., CV = 38%) for 52 squamous cell carcinomas and 0.59 +/- 0.27 for four adenocarcinomas. There were statistically significant differences between the individual tumours (p less than 0.001). From the analysis-of-variance of all the SF2 results it appears to be the surviving fractions below about 0.40 and those above about 0.7 which show significant differences in radiosensitivity between pairs of tumours (p = 0.05). Also 36% of the values of SF2 show significant differences from the mean SF2 of all tumours. The storage of tumour cell suspensions in liquid nitrogen improved the colony-forming efficiency (CFE) but it did not alter the radiosensitivity.
    Citation
    Radiosensitivity testing of primary cervical carcinoma: evaluation of intra- and inter-tumour heterogeneity. 1990, 18 (4):349-56 Radiother Oncol
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/109858
    DOI
    10.1016/0167-8140(90)90115-D
    PubMed ID
    2244021
    Type
    Article
    Language
    en
    ISSN
    0167-8140
    ae974a485f413a2113503eed53cd6c53
    10.1016/0167-8140(90)90115-D
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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