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    A comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states.

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    Authors
    West, Catharine M L
    West, David C
    Kumar, Shant
    Moore, James V
    Affiliation
    CRC Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1990-07
    
    Metadata
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    Abstract
    Bovine aorta endothelial and human colon adenocarcinoma (WiDr) cells were exposed to haematoporphyrin derivative plus light. Cell survival was determined using a [3H]thymidine incorporation and a clonogenic assay for both cell types. The endothelial cells were more sensitive to photodynamic treatment. This could be explained in terms of increased drug uptake into the endothelial cells despite there being no difference in cell volume between the cells. For both tumour and endothelial cells, exponentially growing cells were more sensitive to photodynamic treatment than plateau-phase cells. This was associated with a reduction in drug uptake into plateau-phase endothelial cells. However, there was no difference in uptake into exponentially growing and plateau-phase WiDr cells.
    Citation
    A comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states. 1990, 58 (1):145-56 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/109854
    DOI
    10.1080/09553009014551501
    PubMed ID
    1973432
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/09553009014551501
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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