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    The architecture of bone marrow cell populations.

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    Authors
    Lord, Brian I
    Affiliation
    Cancer Research Campaign Department of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Manchester, England.
    Issue Date
    1990-09
    
    Metadata
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    Abstract
    Marrow is a loosely bound tissue in which hemopoiesis has frequently been considered to be randomly distributed. The case is presented, however, for an organized and structured marrow in which close relationships exist between hemopoietic tissue and a regulatory microenvironment. Distributions of myeloid cells in the mouse femur are described, and a dynamic picture of their movement, with differentiation and maturation from the endosteal surface of the bone to their release via the central venous sinus, is painted. It is also shown that this structure is established within three weeks of birth. By contrast, mature lymphoid cells (but not their progenitors) are uniformly distributed. Regulatory stromal elements in the marrow are also structured and their localization is found to correspond closely to the properties of the progenitor populations. Such structure has potential practical importance, particularly in the field of medical, industrial or accidental radiation exposure where bone may introduce non-uniform dose distributions in the marrow.
    Citation
    The architecture of bone marrow cell populations. 1990, 8 (5):317-31 Int. J. Cell Cloning
    Journal
    International Journal of Cell Cloning
    URI
    http://hdl.handle.net/10541/109851
    DOI
    10.1002/stem.5530080501
    PubMed ID
    2230283
    Type
    Article
    Language
    en
    ISSN
    0737-1454
    ae974a485f413a2113503eed53cd6c53
    10.1002/stem.5530080501
    Scopus Count
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    All Paterson Institute for Cancer Research

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