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    The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells.

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    Authors
    Heyworth, Clare M
    Dexter, T Michael
    Kan, O
    Whetton, Anthony D
    Affiliation
    Experimental Haematology Department, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, United Kingdom.
    Issue Date
    1990
    
    Metadata
    Show full item record
    Abstract
    A multipotent hemopoietic cell line has been employed to assess the influence of the hemopoietic growth factors, IL-3, GM-CSF, G-CSF, and CSF-1 on the processes of self-renewal, the generation of lineage restricted progenitor cells and the production of mature neutrophils and macrophages. At a high concentration of IL-3, the cells undergo self-renewal and demonstrate little or no ability to undergo differentiation in the presence of the other growth factors. In the absence of IL-3, the cells show minimal (GM-CSF) or no (G-CSF or CSF-1) ability to respond to these other growth factors. When combined with a low concentration of IL-3, the ability of the cells to respond to GM-CSF, G-CSF, and CSF-1 is enhanced and a selective preference for the neutrophil or macrophage lineage is seen depending on the combination used, i.e., the presence of CSF-1 preferentially promotes macrophage development and G-CSF preferentially promotes neutrophil development. Conditions optimal for neutrophil development were seen using a combination of low IL-3 concentrations plus GM-CSF plus G-CSF. In such conditions, the cells undergo extensive proliferation and progressively lose their clonogenic potential (i.e., differentiation much greater than self-renewal) and acquire the biochemical markers characteristic of fully mature phagocytes.
    Citation
    The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells. 1990, 2 (2-3):197-211 Growth Factors
    Journal
    Growth Factors
    URI
    http://hdl.handle.net/10541/109848
    DOI
    10.3109/08977199009071506
    PubMed ID
    1692719
    Type
    Article
    Language
    en
    ISSN
    0897-7194
    ae974a485f413a2113503eed53cd6c53
    10.3109/08977199009071506
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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