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dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorRoberts, Stephen Aen
dc.date.accessioned2010-08-18T12:26:10Z
dc.date.available2010-08-18T12:26:10Z
dc.date.issued1990-05
dc.identifier.citationAnalysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units. 1990, 122 (2):155-60 Radiat. Res.en
dc.identifier.issn0033-7587
dc.identifier.pmid2139973
dc.identifier.urihttp://hdl.handle.net/10541/109844
dc.description.abstractThe analysis of 68 published sets of dose-incidence data for marrow failure in different species, using a double-log mortality function, indicates: (a) There is more heterogeneity, i.e. greater sums-of-squares per degree of freedom, within the data sets for mouse than for larger species (monkey, dog, sheep, goat, pig). (b) For mice the curves for acute doses are characterized by a D0 of about 100 cGy for tissue-rescuing units (or target cells), which are depleted at most to about 3 x 10(-4) at LD50. (c) Larger species are much less tolerant to target-cell depletion, the corresponding level being consistently in the range of 10(-2)-10(-3) at LD50. Also, the D0 is often lower (approximately 55 cGy), which is compatible in the dog with such a value for hemopoietic progenitor cells. (d) With larger species there is an unexpected reduction in heterogeneity when the dose rate is lower, which gives a D0 lower than expected and a higher extrapolate. It is concluded that the position and slope of the dose-incidence curves are compatible with interpretations based primarily on target-cell number and survival characteristics, modified by additional heterogeneity factors.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals
dc.subject.meshBone Marrow
dc.subject.meshDogs
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshGoats
dc.subject.meshHaplorhini
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshMeta-Analysis as Topic
dc.subject.meshRadiation Tolerance
dc.subject.meshRats
dc.subject.meshSheep
dc.subject.meshSpecies Specificity
dc.subject.meshSwine
dc.titleAnalysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen
html.description.abstractThe analysis of 68 published sets of dose-incidence data for marrow failure in different species, using a double-log mortality function, indicates: (a) There is more heterogeneity, i.e. greater sums-of-squares per degree of freedom, within the data sets for mouse than for larger species (monkey, dog, sheep, goat, pig). (b) For mice the curves for acute doses are characterized by a D0 of about 100 cGy for tissue-rescuing units (or target cells), which are depleted at most to about 3 x 10(-4) at LD50. (c) Larger species are much less tolerant to target-cell depletion, the corresponding level being consistently in the range of 10(-2)-10(-3) at LD50. Also, the D0 is often lower (approximately 55 cGy), which is compatible in the dog with such a value for hemopoietic progenitor cells. (d) With larger species there is an unexpected reduction in heterogeneity when the dose rate is lower, which gives a D0 lower than expected and a higher extrapolate. It is concluded that the position and slope of the dose-incidence curves are compatible with interpretations based primarily on target-cell number and survival characteristics, modified by additional heterogeneity factors.


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