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    A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor.

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    Authors
    Molineux, Graham
    Pojda, Z
    Dexter, T Michael
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
    Issue Date
    1990-02-01
    
    Metadata
    Show full item record
    Abstract
    Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces leukocytosis in vivo in both intact and splenectomized mice. Full dose response data showed a plateau in this effect at doses over 500 micrograms rhG-CSF/kg body weight/d in intact mice. The effect is magnified in splenectomized mice, where leukocyte numbers reach 100 x 10(6) mL after 4 days' treatment at 250 micrograms/kg/d. Further hematopoietic precursor populations are also affected in both marrow and the spleen; in general, marrow parameters were depressed, while splenic populations were enlarged. In splenectomized mice, both blood-borne stem cells were enhanced, and foci of extramedullary hematopoiesis were enlarged in addition to the effects seen in intact mice. In the marrow of splenectomized and intact mice treated with a high dose of G-CSF, erythroid suppression in the marrow was confirmed with radioactive iron. Our studies confirm and extend previous work on the mode of action of G-CSF, and indicate that side effects of high dose G-CSF therapy might include erythroid suppression in the bone marrow.
    Citation
    A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor. 1990, 75 (3):563-9 Blood
    Journal
    Blood
    URI
    http://hdl.handle.net/10541/109834
    PubMed ID
    1688718
    Type
    Article
    Language
    en
    ISSN
    0006-4971
    Collections
    All Paterson Institute for Cancer Research

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