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dc.contributor.authorMitchell, Erika L D
dc.contributor.authorSantibanez-Koref, Mauro F
dc.date.accessioned2010-08-18T13:13:43Z
dc.date.available2010-08-18T13:13:43Z
dc.date.issued1990-11
dc.identifier.citation1p13 is the most frequently involved band in structural chromosomal rearrangements in human breast cancer. 1990, 2 (4):278-89 Genes Chromosomes Canceren
dc.identifier.issn1045-2257
dc.identifier.pmid2268577
dc.identifier.doi10.1002/gcc.2870020405
dc.identifier.urihttp://hdl.handle.net/10541/109831
dc.description.abstractCytogenetic data on 14 breast carcinomas were examined to determine which chromosome arms and bands are preferentially involved in structural chromosome changes. Chromosome arms 17p, 16q, and 1p and band 1p13 were found to be significantly involved. A review of the world literature confirmed 1p as being the most frequently involved arm in structural chromosome changes in breast cancer and 1p13 as being the band most frequently involved in such changes. The two sets of results were pooled, and the analysis of 113 tumours revealed 229 of 304 bands to be involved, with 1p13 affected in 20% of the tumours.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms
dc.subject.meshCarcinoma
dc.subject.meshChromosome Aberrations
dc.subject.meshChromosome Banding
dc.subject.meshChromosomes, Human, Pair 1
dc.subject.meshGene Rearrangement
dc.subject.meshHumans
dc.subject.meshKaryotyping
dc.title1p13 is the most frequently involved band in structural chromosomal rearrangements in human breast cancer.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalGenes, Chromosomes & Canceren
html.description.abstractCytogenetic data on 14 breast carcinomas were examined to determine which chromosome arms and bands are preferentially involved in structural chromosome changes. Chromosome arms 17p, 16q, and 1p and band 1p13 were found to be significantly involved. A review of the world literature confirmed 1p as being the most frequently involved arm in structural chromosome changes in breast cancer and 1p13 as being the band most frequently involved in such changes. The two sets of results were pooled, and the analysis of 113 tumours revealed 229 of 304 bands to be involved, with 1p13 affected in 20% of the tumours.


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