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    Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6.

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    Authors
    Littler, Edward
    Lawrence, G
    Liu, Mei-Ying
    Barrell, B G
    Arrand, John R
    Affiliation
    Department of Molecular Biology, Christie Hospital & Holt Radium Institute, Manchester, United Kingdom.
    Issue Date
    1990-02
    
    Metadata
    Show full item record
    Abstract
    DNA sequence analysis of part of the human herpesvirus 6 (HHV-6) genome led to the identification of an open reading frame with amino acid sequence homology to the major capsid proteins (MCP) of other HHVs. DIAGON analysis showed that the closest homology was with human cytomegalovirus. Plasmids were constructed which were shown to express the HHV-6 MCP as either the entire open reading frame or as portions of it, and the recombinant-produced proteins were used to raise antisera. The antisera were shown by immunofluorescence to react with HHV-6-infected lymphoblastoid cells and in Western blots with a 135-kilodalton protein specific to HHV-6-infected cells. The recombinant protein expressed from the entire HHV-6 MCP gene was detected only weakly in Western blot assays with normal HHV-6-positive human sera as a probe.
    Citation
    Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6. 1990, 64 (2):714-22 J. Virol.
    Journal
    Journal of Virology
    URI
    http://hdl.handle.net/10541/109813
    PubMed ID
    2153237
    Type
    Article
    Language
    en
    ISSN
    0022-538X
    Collections
    All Paterson Institute for Cancer Research

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