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    Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma.

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    Authors
    Ferguson, Janice E
    Schor, Ana M
    Howell, Anthony
    Ferguson, M W
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.
    Issue Date
    1990-02
    
    Metadata
    Show full item record
    Abstract
    Tenascin is a novel extracellular matrix glycoprotein which appears to have a major role in tissue development. Previous studies have stated that tenascin is absent from the normal human, rat and mouse breast, its distribution being restricted to embryonic and malignant mammary tissues. No previous studies have investigated tenascin distribution as a function of the normal menstrual cycle. Therefore this study addresses the cyclical appearance of tenascin in the normal breast and associated changes in distribution in preinvasive cancer (carcinoma-in-situ) and invasive infiltrating ductal carcinoma. Tenascin is present in the normal human adult mammary gland, principally in the basement membrane, sub-basement-membrane zone and delimiting layer of fibroblasts around the ductules. Both the distribution and quantity of tenascin change during the menstrual cycle. In carcinoma-in-situ (preinvasive cancer) tenascin is present in the attenuated basement membrane/sub-basement-membrane zone around the expanded ductules and in small amounts in the stroma. In infiltrating ductal carcinoma, tenascin is absent from the remnants of the basement membrane and sub-basement-membrane zone but greatly increased in the adjacent intralobular and interlobular stroma. Therefore, if tenascin is used as a basement membrane/sub-basement-membrane marker for distinguishing carcinoma-in-situ from invasive ductal carcinoma, the time of the menstrual cycle is of importance in interpreting the biopsy appearance. This study suggests that the optimal time for biopsy is between weeks 3 and 4 of the cycle, to avoid confusion between the normal low levels of tenascin (due to hormonal status) and those due to microinvasive disease.(ABSTRACT TRUNCATED AT 250 WORDS)
    Citation
    Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma. 1990, 42 (3):199-207 Differentiation
    Journal
    Differentiation
    URI
    http://hdl.handle.net/10541/109811
    DOI
    10.1111/j.1432-0436.1990.tb00762.x
    PubMed ID
    1692795
    Type
    Article
    Language
    en
    ISSN
    0301-4681
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1432-0436.1990.tb00762.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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