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dc.contributor.authorDyke, G Wen
dc.contributor.authorCraven, J Len
dc.contributor.authorHall, Ren
dc.contributor.authorCooper, Donald Pen
dc.contributor.authorSoballa, Gen
dc.contributor.authorGarner, R Cen
dc.date.accessioned2010-08-18T09:26:25Z
dc.date.available2010-08-18T09:26:25Z
dc.date.issued1990-11-05
dc.identifier.citationO6-alkyltransferase activity in normal human gastric mucosa. 1990, 54 (3):147-51 Cancer Lett.en
dc.identifier.issn0304-3835
dc.identifier.pmid2224842
dc.identifier.doi10.1016/0304-3835(90)90036-W
dc.identifier.urihttp://hdl.handle.net/10541/109810
dc.description.abstractThe spectrum of activity of the DNA repair enzyme O6-alkyltransferase has been studied in a large series of normal stomachs in order to establish the baseline range of values for this enzyme. Sixty-eight patients with histologically normal stomachs were biopsied during the course of upper gastrointestinal endoscopy and the biopsies assayed for O6-alkyl-transferase activity. A wide spectrum of activity was found with values ranging from 38 fmol O6-guanine extracted/mg protein to over 400 fmol/mg. This suggests that there may be wide inter-individual differences in susceptibility to alkylating actions in the human gastric mucosa.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshDNA
dc.subject.meshFemale
dc.subject.meshGastric Mucosa
dc.subject.meshHumans
dc.subject.meshKinetics
dc.subject.meshMale
dc.subject.meshMethyltransferases
dc.subject.meshMiddle Aged
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase
dc.subject.meshPilot Projects
dc.subject.meshTritium
dc.titleO6-alkyltransferase activity in normal human gastric mucosa.en
dc.typeArticleen
dc.contributor.departmentCancer Research Unit, University of York, Heslington, U.K.en
dc.identifier.journalCancer Lettersen
html.description.abstractThe spectrum of activity of the DNA repair enzyme O6-alkyltransferase has been studied in a large series of normal stomachs in order to establish the baseline range of values for this enzyme. Sixty-eight patients with histologically normal stomachs were biopsied during the course of upper gastrointestinal endoscopy and the biopsies assayed for O6-alkyl-transferase activity. A wide spectrum of activity was found with values ranging from 38 fmol O6-guanine extracted/mg protein to over 400 fmol/mg. This suggests that there may be wide inter-individual differences in susceptibility to alkylating actions in the human gastric mucosa.


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