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    O6-alkyltransferase activity in normal human gastric mucosa.

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    Authors
    Dyke, G W
    Craven, J L
    Hall, R
    Cooper, Donald P
    Soballa, G
    Garner, R C
    Affiliation
    Cancer Research Unit, University of York, Heslington, U.K.
    Issue Date
    1990-11-05
    
    Metadata
    Show full item record
    Abstract
    The spectrum of activity of the DNA repair enzyme O6-alkyltransferase has been studied in a large series of normal stomachs in order to establish the baseline range of values for this enzyme. Sixty-eight patients with histologically normal stomachs were biopsied during the course of upper gastrointestinal endoscopy and the biopsies assayed for O6-alkyl-transferase activity. A wide spectrum of activity was found with values ranging from 38 fmol O6-guanine extracted/mg protein to over 400 fmol/mg. This suggests that there may be wide inter-individual differences in susceptibility to alkylating actions in the human gastric mucosa.
    Citation
    O6-alkyltransferase activity in normal human gastric mucosa. 1990, 54 (3):147-51 Cancer Lett.
    Journal
    Cancer Letters
    URI
    http://hdl.handle.net/10541/109810
    DOI
    10.1016/0304-3835(90)90036-W
    PubMed ID
    2224842
    Type
    Article
    Language
    en
    ISSN
    0304-3835
    ae974a485f413a2113503eed53cd6c53
    10.1016/0304-3835(90)90036-W
    Scopus Count
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