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    The effects of the platinum anti-tumour agents on renal cell kinetics and the response to a second cytotoxic agent.

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    Authors
    Ewen, C
    Hendry, Jolyon H
    Affiliation
    Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1990-03
    
    Metadata
    Show full item record
    Abstract
    Following 15 mg kg-1 cisplatin to mice, the labelling index (LI) in the kidney decreased from 0.4% to less than 0.01% at 1-3 d, increased to 1.9% at day 16 and returned to control levels by day 30. Cytotoxicity was assessed by counts of viable tubule cross-sections and recovery was incomplete up to 14 months after treatment. Cisplatin treatment impaired the regeneration response to a dose of 16 mg kg-1 uranyl nitrate (UN) given 14 d after cisplatin when assessed by an increase in LI and sub-capsular tubule count. However, there was recovery with greater time intervals. At nine months after cisplatin there was no difference in response to UN of controls and mice previously treated by cisplatin. Prior treatment with paraplatin or iproplatin at LD50 doses produced not only no histopathological changes but also no impairment of the subsequent responses to UN.
    Citation
    The effects of the platinum anti-tumour agents on renal cell kinetics and the response to a second cytotoxic agent. 1990, 23 (2):61-70 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/109798
    DOI
    10.1111/j.1365-2184.1990.tb01333.x
    PubMed ID
    2180572
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1990.tb01333.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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