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    The biochemistry and biology of the myeloid haemopoietic cell growth factors.

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    Authors
    Heyworth, Clare M
    Vallance, S J
    Whetton, Anthony D
    Dexter, T Michael
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
    Issue Date
    1990
    
    Metadata
    Show full item record
    Abstract
    In the adult, blood cell production or haemopoiesis takes place mainly in the bone marrow. The blood cell types produced are a reflection of the needs of the organism at any moment, for example bacterial infection leads to a large increase in neutrophil production. The rate and scale of blood cell production in vivo are regulated, at least in part, by the synthesis and release of specific cytokines both within the bone marrow and also from other tissues. Here we detail the range of cytokines which act directly on haemopoietic stem cells and myeloid progenitor cells. Also cellular systems which will permit the elucidation of the specific interactions between these various cytokines which regulate stem cell self-renewal, differentiation and proliferation are described.
    Citation
    The biochemistry and biology of the myeloid haemopoietic cell growth factors. 1990, 13:57-74 J. Cell Sci. Suppl.
    Journal
    Journal of Cell Science. Supplement
    URI
    http://hdl.handle.net/10541/109795
    PubMed ID
    2084118
    Type
    Article
    Language
    en
    ISSN
    0269-3518
    Collections
    All Paterson Institute for Cancer Research

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