Sarcomas in three generations of a family with neurofibromatosis.
Affiliation
Department of Epidemiology and Social Oncology, Christie Hospital and Holt Radium Institute, Manchester, England.Issue Date
1990-04
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The development of sarcomas in three generations of a family with neurofibromatosis (NF) is described. A 7-month-old boy developed a prostatic rhabdomyosarcoma. Family history revealed that his maternal grandmother had died of a malignant peripheral nerve sheath tumor at age 37 years and had been affected with neurofibromatosis. His mother (aged 36 years) has also developed a malignant peripheral nerve sheath tumor and NF has been confirmed in both mother and son. This family illustrates a cluster of sarcomas associated with NF and shows the importance of thorough investigation of reported family illnesses.Citation
Sarcomas in three generations of a family with neurofibromatosis. 1990, 45 (2):245-8 Cancer Genet CytogenetJournal
Cancer Genetics and CytogeneticsDOI
10.1016/0165-4608(90)90089-SPubMed ID
2107963Type
ArticleLanguage
enISSN
0165-4608ae974a485f413a2113503eed53cd6c53
10.1016/0165-4608(90)90089-S
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