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dc.contributor.authorHartley, Ann L
dc.contributor.authorBirch, Jillian M
dc.contributor.authorKelsey, Anna M
dc.contributor.authorJones, P H
dc.contributor.authorHarris, Martin
dc.contributor.authorBlair, Val
dc.date.accessioned2010-08-17T17:12:15Z
dc.date.available2010-08-17T17:12:15Z
dc.date.issued1990
dc.identifier.citationEpidemiological and familial aspects of hepatoblastoma. 1990, 18 (2):103-9 Med. Pediatr Oncolen
dc.identifier.issn0098-1532
dc.identifier.pmid2154662
dc.identifier.doi10.1002/mpo.2950180204
dc.identifier.urihttp://hdl.handle.net/10541/109782
dc.description.abstractData on the 20 cases of hepatoblastoma registered with the Manchester Children's Tumour Registry between 1954 and 1988 are presented. The cases represent about 0.6% of childhood malignancies and show a male:female ratio of 2.3:1. Age at presentation was almost always under 2 1/2 years. Cancer rates in close relatives were not significantly different from those expected. One family was confirmed as having Gardner syndrome, but the presence of other syndromes e.g., Beckwith-Wiedemann, could not be reliably detected in this retrospective series. The need to take an extensive pedigree and for clinical examination of other family members at the time of the child's diagnosis is emphasized.
dc.language.isoenen
dc.subjectLiver Canceren
dc.subject.meshAdult
dc.subject.meshCarcinoma, Hepatocellular
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDrug Therapy
dc.subject.meshEngland
dc.subject.meshFamily
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshLiver Neoplasms
dc.subject.meshMale
dc.subject.meshMedical History Taking
dc.subject.meshOccupations
dc.subject.meshPedigree
dc.subject.meshPregnancy
dc.subject.meshRegistries
dc.titleEpidemiological and familial aspects of hepatoblastoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology and Social Oncology, Christie Hospital and Holt Radium Institute, Manchester, England.en
dc.identifier.journalMedical and Pediatric Oncologyen
html.description.abstractData on the 20 cases of hepatoblastoma registered with the Manchester Children's Tumour Registry between 1954 and 1988 are presented. The cases represent about 0.6% of childhood malignancies and show a male:female ratio of 2.3:1. Age at presentation was almost always under 2 1/2 years. Cancer rates in close relatives were not significantly different from those expected. One family was confirmed as having Gardner syndrome, but the presence of other syndromes e.g., Beckwith-Wiedemann, could not be reliably detected in this retrospective series. The need to take an extensive pedigree and for clinical examination of other family members at the time of the child's diagnosis is emphasized.


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