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dc.contributor.authorMolineux, Graham
dc.contributor.authorPojda, Z
dc.contributor.authorHampson, Ian N
dc.contributor.authorLord, Brian I
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-08-17T11:29:41Z
dc.date.available2010-08-17T11:29:41Z
dc.date.issued1990-11-15
dc.identifier.citationTransplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. 1990, 76 (10):2153-8 Blooden
dc.identifier.issn0006-4971
dc.identifier.pmid1700732
dc.identifier.urihttp://hdl.handle.net/10541/109756
dc.description.abstractThe major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow transplantation in humans, primates and rodents. In addition, it has been reported that migration of committed progenitor cells to the blood occurs during G-CSF therapy. In this article, by using sex mismatched transplants and a molecular probe for Y-chromosome specific DNA sequences, we show that among the peripheral blood cells during G-CSF therapy are substantial numbers of primitive stem cells capable of (1) reconstituting the hematopoietic system in the long term, and (2) making a contribution to the lymphoid populations of the thymus, in radiation ablated recipients. These data suggest that blood from patients treated with G-CSF may provide a convenient source of the most primitive stem cells for autologous or allogeneic bone marrow transplantation.
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals
dc.subject.meshBone Marrow Transplantation
dc.subject.meshFemale
dc.subject.meshGraft Survival
dc.subject.meshGranulocyte Colony-Stimulating Factor
dc.subject.meshHematopoiesis
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshNeutrophils
dc.titleTransplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalBlooden
html.description.abstractThe major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow transplantation in humans, primates and rodents. In addition, it has been reported that migration of committed progenitor cells to the blood occurs during G-CSF therapy. In this article, by using sex mismatched transplants and a molecular probe for Y-chromosome specific DNA sequences, we show that among the peripheral blood cells during G-CSF therapy are substantial numbers of primitive stem cells capable of (1) reconstituting the hematopoietic system in the long term, and (2) making a contribution to the lymphoid populations of the thymus, in radiation ablated recipients. These data suggest that blood from patients treated with G-CSF may provide a convenient source of the most primitive stem cells for autologous or allogeneic bone marrow transplantation.


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