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    Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.

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    Authors
    Molineux, Graham
    Pojda, Z
    Hampson, Ian N
    Lord, Brian I
    Dexter, T Michael
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
    Issue Date
    1990-11-15
    
    Metadata
    Show full item record
    Abstract
    The major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow transplantation in humans, primates and rodents. In addition, it has been reported that migration of committed progenitor cells to the blood occurs during G-CSF therapy. In this article, by using sex mismatched transplants and a molecular probe for Y-chromosome specific DNA sequences, we show that among the peripheral blood cells during G-CSF therapy are substantial numbers of primitive stem cells capable of (1) reconstituting the hematopoietic system in the long term, and (2) making a contribution to the lymphoid populations of the thymus, in radiation ablated recipients. These data suggest that blood from patients treated with G-CSF may provide a convenient source of the most primitive stem cells for autologous or allogeneic bone marrow transplantation.
    Citation
    Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. 1990, 76 (10):2153-8 Blood
    Journal
    Blood
    URI
    http://hdl.handle.net/10541/109756
    PubMed ID
    1700732
    Type
    Article
    Language
    en
    ISSN
    0006-4971
    Collections
    All Paterson Institute for Cancer Research

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