• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Pojda, Z
    Molineux, Graham
    Dexter, T Michael
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, England.
    Issue Date
    1990-01
    
    Metadata
    Show full item record
    Abstract
    Recombinant human granulocyte colony-stimulating factor (rhG-CSF) was injected s.c., twice daily, into normal adult male BDF1 mice for a period of 4-5 days in doses ranging from 10 to 2500 micrograms/kg/day. The number of peripheral blood cells and their morphology was examined daily from the beginning of the experiment for 6 days. On the 5th day of treatment parameters such as spleen weight and cellularity, bone marrow morphology and cellularity, content of granulocyte-macrophage colony-forming cells (GM-CFC) or multipotential stem cells (CFU-S) in spleen and marrow, and also histology of lung and liver were examined. We observed a dose-dependent increase in the number of blood neutrophils, and an increase in weight, cellularity, and numbers of GM-CFC and CFU-S in the spleen. In the bone marrow, cellularity decreased to 40% of normal. Numbers of GM-CFC and CFU-S in marrow were also decreased, and examination of marrow morphology revealed an inhibition of erythropoiesis.
    Citation
    Hemopoietic effects of short-term in vivo treatment of mice with various doses of rhG-CSF. 1990, 18 (1):27-31 Exp. Hematol.
    Journal
    Experimental Hematology
    URI
    http://hdl.handle.net/10541/109745
    PubMed ID
    1688807
    Type
    Article
    Language
    en
    ISSN
    0301-472X
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) on acute radiation hematopoietic injury in mice.
    • Authors: Tanikawa S, Nakao I, Tsuneoka K, Nara N
    • Issue date: 1989 Sep
    • The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors.
    • Authors: Broxmeyer HE, Williams DE, Hangoc G, Cooper S, Gentile P, Shen RN, Ralph P, Gillis S, Bicknell DC
    • Issue date: 1987
    • Effect of cytokine treatment (granulocyte colony-stimulating factor and stem cell factor) on hematopoiesis and the circulating pool of hematopoietic stem cells in mice.
    • Authors: Drize N, Chertkov J, Samoilina N, Zander A
    • Issue date: 1996 Jun
    • Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. Comparison and interactions with recombinant human granulocyte-macrophage and granulocyte colony-stimulating factors.
    • Authors: Ottmann OG, Abboud M, Welte K, Souza LM, Pelus LM
    • Issue date: 1989 Feb
    • Effect of recombinant human granulocyte colony-stimulating factor on hematopoiesis in normal cats.
    • Authors: Fulton R, Gasper PW, Ogilvie GK, Boone TC, Dornsife RE
    • Issue date: 1991 Sep
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.