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dc.contributor.authorTesta, Nydia G
dc.contributor.authorDexter, T Michael
dc.date.accessioned2010-08-17T11:25:09Z
dc.date.available2010-08-17T11:25:09Z
dc.date.issued1990-05
dc.identifier.citationCell lineages in haemopoiesis: comments on their regulation. 1990, 2 (3):167-72 Semin. Immunol.en
dc.identifier.issn1044-5323
dc.identifier.pmid1717053
dc.identifier.urihttp://hdl.handle.net/10541/109742
dc.description.abstractThe regulation of cell production and the determination of cell lineage in haemopoiesis are the result of multiple processes involving cell-cell interactions and the action of specific haemopoietic growth factors as well as other cytokines. Additive and synergistic interactions between these factors, and also with those involved in the regulation of lymphopoiesis have been described, which involve modulation of the growth and differentiation of haematopoietic precursors. However, the mechanisms which determine the self-renewal and the differentiation of the pluripotent lymphohaemopoietic stem cell remain largely undefined.
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshAnimals
dc.subject.meshCell Communication
dc.subject.meshCell Differentiation
dc.subject.meshErythropoietin
dc.subject.meshGranulocyte Colony-Stimulating Factor
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor
dc.subject.meshHematopoiesis
dc.subject.meshHematopoietic Cell Growth Factors
dc.subject.meshHumans
dc.subject.meshInterleukin-3
dc.subject.meshMacrophage Colony-Stimulating Factor
dc.subject.meshMice
dc.subject.meshStem Cells
dc.titleCell lineages in haemopoiesis: comments on their regulation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalSeminars in Immunologyen
html.description.abstractThe regulation of cell production and the determination of cell lineage in haemopoiesis are the result of multiple processes involving cell-cell interactions and the action of specific haemopoietic growth factors as well as other cytokines. Additive and synergistic interactions between these factors, and also with those involved in the regulation of lymphopoiesis have been described, which involve modulation of the growth and differentiation of haematopoietic precursors. However, the mechanisms which determine the self-renewal and the differentiation of the pluripotent lymphohaemopoietic stem cell remain largely undefined.


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