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    Conservation of the breast using two different radiotherapy techniques: interim report of a clinical trial.

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    Authors
    Ribeiro, G
    Dunn, Gillian
    Swindell, Ric
    Harris, Martin
    Banerjee, Saumitra S
    Affiliation
    Department of Radiotherapy, Christie Hospital, Manchester, UK.
    Issue Date
    1990-01
    
    Metadata
    Show full item record
    Abstract
    Patients with a clinically palpable breast carcinoma, 4 cm or less in diameter, and with no palpable nodes in the axilla were prospectively entered into a randomized clinical trial. A total of 713 patients were registered between November 1982 and December 1987, of whom 708 are evaluable at a median follow-up of 37 months. Following excision of the primary tumour, patients were randomly allocated either to have radiotherapy to the affected quadrant only (LF group) or to the whole breast and regional lymph node areas (WF group). No adjuvant hormone or chemotherapy was prescribed. The primary tumour was reported as completely excised histologically in 80% of cases, incompletely excised in 10%, and no estimate was possible in 10%. At six years from first randomization, 96% of the WF group and 92% of the LF group have remained free of breast recurrence (94% and 87% actuarial breast recurrence-free survival at 5 years). Part of the difference may be explained by the 20% recurrence rate in the breast for lobular carcinomas treated within the LF group. Of the WF group 14 patients (4%) developed recurrent disease in the axilla, compared to 50 patients (14%) in the LF group (95% and 86% actuarial axillary recurrent-free survival at 5 years). Patients with primary tumours histologically 1 cm or less in diameter had a 98% actuarial 5-year survival compared with 74% for those with tumours measuring 2 cm or more in diameter (P = 0.003). Continued follow-up of these patients will provide further information on the factors governing local/regional recurrence.
    Citation
    Conservation of the breast using two different radiotherapy techniques: interim report of a clinical trial. 1990, 2 (1):27-34 Clin Oncol (R Coll Radiol)
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/109736
    DOI
    10.1016/S0936-6555(05)80215-8
    PubMed ID
    2261385
    Type
    Article
    Language
    en
    ISSN
    0936-6555
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0936-6555(05)80215-8
    Scopus Count
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