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dc.contributor.authorBirch, Jillian M
dc.contributor.authorHartley, Ann L
dc.contributor.authorTeare, M Dawn
dc.contributor.authorBlair, Val
dc.contributor.authorMcKinney, Patricia A
dc.contributor.authorMann, J R
dc.contributor.authorStiller, C A
dc.contributor.authorDraper, G J
dc.contributor.authorJohnston, H E
dc.contributor.authorCartwright, R A
dc.date.accessioned2010-08-17T08:23:39Z
dc.date.available2010-08-17T08:23:39Z
dc.date.issued1990
dc.identifier.citationThe inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours. 1990, 4 (1):17-25 Br J Neurosurgen
dc.identifier.issn0268-8697
dc.identifier.pmid2334522
dc.identifier.doi10.1002/bjs.1800770502
dc.identifier.urihttp://hdl.handle.net/10541/109693
dc.description.abstractTumours of the central nervous system comprise 23% of all childhood cancers and form the most common group of solid malignancies. Little is know about their aetiology. The present report concerns the results of a case-control study of 78 incident cases of central nervous system tumours in children. No case-control differences were detected for the following: pre-natal diagnostic X-rays, general anaesthetics during pregnancy, pregnancy infections, pregnancy drugs (including sedatives, tranquillizers and anti-convulsants), alcohol consumption in pregnancy, child's birthweight, breast-feeding, childhood illnesses, previous medication in the child. A significant excess of case mothers had suffered from diseases of the nervous system (RR 2.6). There was a deficit of children who had been immunised among the case children which approached significance, and an excess of congenital abnormalities among cases which also approached significance. There was a small excess of neoplastic disease among case parents. The results of this study suggest that in our patients genetic rather than environmental factors are more important, but the small numbers included in the present study meant that no definite conclusions could be reached.
dc.language.isoenen
dc.subjectNervous System Canceren
dc.subject.meshAbnormalities, Multiple
dc.subject.meshCase-Control Studies
dc.subject.meshCentral Nervous System Diseases
dc.subject.meshChild
dc.subject.meshFamily Health
dc.subject.meshFemale
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshLabor, Obstetric
dc.subject.meshMale
dc.subject.meshNervous System Neoplasms
dc.subject.meshOccupations
dc.subject.meshPregnancy
dc.subject.meshPregnancy Complications
dc.subject.meshRisk Factors
dc.subject.meshSmoking
dc.subject.meshSocial Class
dc.titleThe inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital & Holt Radium Institute, Manchester, United Kingdom.en
dc.identifier.journalBritish Journal of Neurosurgeryen
html.description.abstractTumours of the central nervous system comprise 23% of all childhood cancers and form the most common group of solid malignancies. Little is know about their aetiology. The present report concerns the results of a case-control study of 78 incident cases of central nervous system tumours in children. No case-control differences were detected for the following: pre-natal diagnostic X-rays, general anaesthetics during pregnancy, pregnancy infections, pregnancy drugs (including sedatives, tranquillizers and anti-convulsants), alcohol consumption in pregnancy, child's birthweight, breast-feeding, childhood illnesses, previous medication in the child. A significant excess of case mothers had suffered from diseases of the nervous system (RR 2.6). There was a deficit of children who had been immunised among the case children which approached significance, and an excess of congenital abnormalities among cases which also approached significance. There was a small excess of neoplastic disease among case parents. The results of this study suggest that in our patients genetic rather than environmental factors are more important, but the small numbers included in the present study meant that no definite conclusions could be reached.


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