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Ovarian cancer family and prophylactic choices.

dc.contributor.authorEvans, D Gareth R
dc.contributor.authorRibeiro, G
dc.contributor.authorWarrell, D
dc.contributor.authorDonnai, D
dc.date.accessioned2010-08-16T14:55:58Z
dc.date.available2010-08-16T14:55:58Z
dc.date.issued1992-06
dc.identifier.citationOvarian cancer family and prophylactic choices. 1992, 29 (6):416-8 J. Med. Genet.en
dc.identifier.issn0022-2593
dc.identifier.pmid1320125
dc.identifier.doi10.1136/jmg.29.6.416
dc.identifier.urihttp://hdl.handle.net/10541/109662
dc.description.abstractA subject from a family with ovarian cancer who has developed bilateral medullary carcinoma of the breast at the age of 40 is presented. The family is consistent with dominant inheritance of ovarian cancer and 12 female family members at 12.5%, 25%, and 50% risk, including our case, have undergone bilateral prophylactic oophorectomy and been given hormone replacement therapy. Despite the risk of further primary tumours of the breast our patient chose to have treatment with wide excision and radiotherapy. The implications for screening, prophylaxis, and hormone replacement therapy for this family are discussed.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectOestrogenen
dc.subjectMultiple Primary Canceren
dc.subjectOvarian Canceren
dc.subject.meshAdult
dc.subject.meshBreast Neoplasms
dc.subject.meshCarcinoma
dc.subject.meshCombined Modality Therapy
dc.subject.meshEstrogens, Conjugated (USP)
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms, Multiple Primary
dc.subject.meshOvarian Neoplasms
dc.subject.meshOvariectomy
dc.subject.meshPedigree
dc.subject.meshTamoxifen
dc.titleOvarian cancer family and prophylactic choices.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester.en
dc.identifier.journalJournal of Medical Geneticsen
html.description.abstractA subject from a family with ovarian cancer who has developed bilateral medullary carcinoma of the breast at the age of 40 is presented. The family is consistent with dominant inheritance of ovarian cancer and 12 female family members at 12.5%, 25%, and 50% risk, including our case, have undergone bilateral prophylactic oophorectomy and been given hormone replacement therapy. Despite the risk of further primary tumours of the breast our patient chose to have treatment with wide excision and radiotherapy. The implications for screening, prophylaxis, and hormone replacement therapy for this family are discussed.


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