Authors
Ogilvy-Stuart, Amanda LClark, D J
Wallace, W Hamish B
Gibson, B E
Stevens, R F
Shalet, Stephen M
Donaldson, M D
Affiliation
Royal Hospital for Sick Children, Yorkhill, Glasgow.Issue Date
1992-09
Metadata
Show full item recordAbstract
Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid dysfunction: two with a low thyroxine and raised thyroid stimulating hormone (TSH) concentration and three with a raised TSH and normal thyroxine concentration. Thus the incidence of thyroid dysfunction (16%) is much lower than that reported after single fraction total body irradiation (39-59%). In only two children were abnormalities of the hypothalamic-pituitary-adrenal axis demonstrated. The majority of pubertal children assessed (n = 15) showed evidence of gonadal damage. All the pubertal girls (n = 5) had ovarian failure, although there was evidence of recovery of ovarian function in one girl. All seven boys in late puberty showed evidence of damage to the germinal epithelium, and two of three in early puberty had raised follicle stimulating hormone concentrations. Despite the use of a fractionated total body irradiation regimen, endocrine morbidity is substantial and children undergoing such procedures will require long term endocrine review and management.Citation
Endocrine deficit after fractionated total body irradiation. 1992, 67 (9):1107-10 Arch Dis ChildJournal
Archives of Disease in ChildhoodDOI
10.1136/adc.67.9.1107PubMed ID
1417055Type
ArticleLanguage
enISSN
1468-2044ae974a485f413a2113503eed53cd6c53
10.1136/adc.67.9.1107
Scopus Count
Collections
Related articles
- Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood.
- Authors: Thomas BC, Stanhope R, Plowman PN, Leiper AD
- Issue date: 1993 Jun
- Long-term effects of allogeneic bone marrow transplantation (BMT) on pituitary, gonad, thyroid and adrenal function in adults.
- Authors: Kauppila M, Koskinen P, Irjala K, Remes K, Viikari J
- Issue date: 1998 Aug
- Endocrine disorders following treatment of childhood brain tumours.
- Authors: Livesey EA, Hindmarsh PC, Brook CG, Whitton AC, Bloom HJ, Tobias JS, Godlee JN, Britton J
- Issue date: 1990 Apr
- The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function.
- Authors: Leiper AD, Stanhope R, Lau T, Grant DB, Blacklock H, Chessells JM, Plowman PN
- Issue date: 1987 Dec
- Endocrine status and growth after malignancy treated in childhood or adolescence.
- Authors: Vilska S, Lähteenmäki P, Kaihola HL, Salmi TT
- Issue date: 1988 Jul-Aug