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    Relationship between urinary and serum growth hormone and pubertal status.

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    Authors
    Crowne, E C
    Wallace, W Hamish B
    Shalet, Stephen M
    Addison, G M
    Price, David A
    Affiliation
    Royal Manchester Children's Hospital.
    Issue Date
    1992-01
    
    Metadata
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    Abstract
    Urinary growth hormone (uGH) excretion and serum growth hormone concentrations have been compared in three groups of children. Group 1 consisted of 21 children who had had cranial irradiation as part of their treatment for acute lymphoblastic leukaemia; group 2, 18 normal children; and group 3, 12 boys with constitutional delay in growth and puberty who were in early puberty. Children in groups 1 and 2 each had a 24 hour serum growth hormone profile (sampling every 20 minutes) and concurrent urine collection. The 12 boys in group 3 had a total of 21 profiles (sampling every 15 minutes for 12 hours) and concurrent urine collections. In the prepubertal children (n = 17), in both groups 1 and 2, there was a significant correlation between mean serum growth hormone and total uGHng/g creatinine. There were also significant correlations between total uGHng/g creatinine and both peak serum growth hormone and mean amplitude of the pulses in the growth hormone profile. In the pubertal children (n = 22), in groups 1 and 2, whether combined or in separate groups, there was no significant correlation between total uGHng/g creatinine and mean serum growth hormone, peak serum growth hormone, or mean amplitude of the pulses in the growth hormone profile. In group 3 there were significant correlations between total uGHng/g creatinine and both the mean serum growth hormone and mean amplitude of the pulses in the profile. Therefore uGH estimations appear to correlate well with serum growth hormone profiles in children who are prepubertal or in early puberty, but not in those further advanced in pubertal development. These results may reflect a variation in the renal handling of growth hormone during pubertal development. uGH estimation may be an unreliable screening investigation for growth hormone sufficiency in mid to late puberty.
    Citation
    Relationship between urinary and serum growth hormone and pubertal status. 1992, 67 (1):91-5 Arch Dis Child
    Journal
    Archives of Disease in Childhood
    URI
    http://hdl.handle.net/10541/109639
    DOI
    10.1136/adc.67.1.91
    PubMed ID
    1739346
    Type
    Article
    Language
    en
    ISSN
    1468-2044
    ae974a485f413a2113503eed53cd6c53
    10.1136/adc.67.1.91
    Scopus Count
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