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dc.contributor.authorPrescott, R Jen
dc.contributor.authorRoberts, S Pen
dc.contributor.authorWilliams, Gen
dc.date.accessioned2010-08-16T13:24:13Z
dc.date.available2010-08-16T13:24:13Z
dc.date.issued1992-04
dc.identifier.citationMalignant hyperpyrexia: a rare cause of postoperative death. 1992, 45 (4):361-3 J Clin Patholen
dc.identifier.issn0021-9746
dc.identifier.pmid1577980
dc.identifier.doi10.1136/jcp.45.4.361
dc.identifier.urihttp://hdl.handle.net/10541/109638
dc.description.abstractA middle aged man developed very high fever, status epilepticus, and terminal acute renal failure with myoglobinuria after surgery. A post mortem examination showed widespread muscle necrosis with hypercontraction bands. Muscle enzyme studies and electron microscopic examination disclosed central core disease, a condition closely related to malignant hyperpyrexia. This condition is a genetically inherited disorder which can be triggered by certain volatile anaesthetic agents or Suxamethonium. In this patient the condition may have been triggered by either the Isoflurane or the postoperative status epilepticus.
dc.language.isoenen
dc.subject.meshHumans
dc.subject.meshIsoflurane
dc.subject.meshMale
dc.subject.meshMalignant Hyperthermia
dc.subject.meshMiddle Aged
dc.subject.meshMuscular Diseases
dc.subject.meshNecrosis
dc.subject.meshPostoperative Complications
dc.subject.meshStatus Epilepticus
dc.titleMalignant hyperpyrexia: a rare cause of postoperative death.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital and Holt Radium Institute, Withington, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen
html.description.abstractA middle aged man developed very high fever, status epilepticus, and terminal acute renal failure with myoglobinuria after surgery. A post mortem examination showed widespread muscle necrosis with hypercontraction bands. Muscle enzyme studies and electron microscopic examination disclosed central core disease, a condition closely related to malignant hyperpyrexia. This condition is a genetically inherited disorder which can be triggered by certain volatile anaesthetic agents or Suxamethonium. In this patient the condition may have been triggered by either the Isoflurane or the postoperative status epilepticus.


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