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    Adjuvant tamoxifen for male breast cancer (MBC).

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    Authors
    Ribeiro, G
    Swindell, Ric
    Affiliation
    Department of Clinical Oncology and Medical Statistics, Christie Hospital, Withington, Manchester, UK.
    Issue Date
    1992-02
    
    Metadata
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    Abstract
    A study was started in 1976 whereby patients with Stage II and operable Stage III MBC were given adjuvant Tamoxifen for 1 year, increasing to 2 years from 1988. All patients had axillary nodal involvement. Primary treatment consisted of a radical mastectomy or simple mastectomy with radiotherapy. The rarity of the disease precluded a randomised trial. Thirty-nine patients are available for analysis at a median follow-up of 49 months. The actuarial survival of the Tamoxifen treated patients is 61% (range 42-80%) at 5 years compared to 44% (range 35-53%) for historical controls (P = 0.006). Disease-free survival was 56% (37-75%) vs 28% (17-33%) at 5 years (P = 0.005). There were no serious side-effects recorded. The conclusion from this, the first reported series on adjuvant Tamoxifen therapy for MBC, is that significant improvement in disease-free survival can be achieved with minimal upset to the patients. Recruitment to the study continues.
    Citation
    Adjuvant tamoxifen for male breast cancer (MBC). 1992, 65 (2):252-4 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/109636
    PubMed ID
    1739625
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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