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dc.contributor.authorHarrison, Christine J
dc.date.accessioned2010-08-16T14:08:45Z
dc.date.available2010-08-16T14:08:45Z
dc.date.issued1992-10
dc.identifier.citationTranslocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992, 5 (3):252-4 Genes Chromosomes Canceren
dc.identifier.issn1045-2257
dc.identifier.pmid1384679
dc.identifier.doi10.1002/gcc.2870050313
dc.identifier.urihttp://hdl.handle.net/10541/109630
dc.description.abstractSix cases of acute myeloid leukemia (AML) with translocations involving 12p are described. The patients were one child age 7 yrs and five adults with an age range of 20-66 yrs (median 46 yrs). In two patients AML followed treatment for acute lymphoblastic leukemia (ALL), in one case after 11 years disease-free survival. Of the remaining four patients, two had been occupationally exposed to possible mutagens and three had a previous myelodysplastic phase. Two patients achieved complete remission; survival for the six cases was between 1 and 24 months (median 6.5 months). The breakpoints in 12p occurred in p11, p12, and p13, indicating that several sites are important in these rearrangements, and it is suggested that t(12;17)(p11;q11) is a new nonrandom abnormality in AML.
dc.language.isoenen
dc.subjectMyeloid Leukaemiaen
dc.subjectSecond Primary Canceren
dc.subject.meshAcute Disease
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChild
dc.subject.meshChromosomes, Human, Pair 12
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLeukemia, Myeloid
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMutagens
dc.subject.meshMyelodysplastic Syndromes
dc.subject.meshNeoplasms, Second Primary
dc.subject.meshTranslocation, Genetic
dc.titleTranslocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents.en
dc.typeArticleen
dc.contributor.departmentUKCCG, Dept. of Haematology, The Royal Free Hospital and School of Medicine, Pond St,. London NW3 2QG, UK.en
dc.identifier.journalGenes, Chromosomes & Canceren
html.description.abstractSix cases of acute myeloid leukemia (AML) with translocations involving 12p are described. The patients were one child age 7 yrs and five adults with an age range of 20-66 yrs (median 46 yrs). In two patients AML followed treatment for acute lymphoblastic leukemia (ALL), in one case after 11 years disease-free survival. Of the remaining four patients, two had been occupationally exposed to possible mutagens and three had a previous myelodysplastic phase. Two patients achieved complete remission; survival for the six cases was between 1 and 24 months (median 6.5 months). The breakpoints in 12p occurred in p11, p12, and p13, indicating that several sites are important in these rearrangements, and it is suggested that t(12;17)(p11;q11) is a new nonrandom abnormality in AML.


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