Doxorubicin in advanced breast cancer: influence of schedule on response, survival and quality of life.
AuthorsRichards, M A
Ramirez, A J
Twelves, C J
Ferguson, Janice E
Gregory, W M
AffiliationImperial Cancer Research Fund, Guy's Hospital, London, U.K.
MetadataShow full item record
AbstractThe influence of scheduling of doxorubicin on response, survival and quality of life was assessed in a randomised trial in patients with advanced breast cancer, none of whom had previously received cytotoxic chemotherapy for advanced disease. 28 patients received 75 mg/m2 doxorubicin every 3 weeks for four courses (arm 1) and 31 patients received 25 mg/m2 weekly for 12 courses (arm 2). Response rates and median time to progression were similar in the two arms and median survival was 8 months in both arms. However, amongst patients receiving treatment every 3 weeks, psychological distress measured using the Rotterdam symptom checklist fell significantly over the course; no such change was observed in those treated weekly. Physical symptoms related to cancer improved during treatment similarly for both groups.
CitationDoxorubicin in advanced breast cancer: influence of schedule on response, survival and quality of life. 1992, 28A (6-7):1023-8 Eur J Cancer
JournalEuropean Journal of Cancer
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