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    Primary malignant lymphoma of the thyroid: a clinicopathological analysis.

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    Authors
    Logue, John P
    Hale, R J
    Stewart, Alan L
    Duthie, M B
    Banerjee, Saumitra S
    Affiliation
    Department of Radiotherapy and Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1992
    
    Metadata
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    Abstract
    A retrospective analysis of 70 patients with primary malignant lymphoma of the thyroid treated at this institute between 1965-1983 has been conducted. The clinicopathological features and prognostic factors have been studied. The mean age was 67.5 years and there was a marked female:male ratio of 8:1. A total of 32 (45.7%) Stage IE and 38 (54.3%) Stage IIE patients were identified. In 64 cases histological material was reviewed and classified employing the Kiel classification. All the tumors were of B cell lineage and the majority were follicle center cell type. A biopsy only was performed in 27 patients, lobectomy in 11 patients, subtotal thyroidectomy in 27 and macroscopic thyroidectomy in 5 patients. All patients were treated with radiotherapy. The overall 5-year survival was 42%, with 63% for Stage IE and 27% for Stage IIE. The corrected overall 5-year survival was 49% with 68% for Stage IE and 36% for Stage IIE. The corresponding overall relapse free survival was 42% with 60% for Stage IE, and 31% for Stage IIE. Factors of prognostic significance for relapse and survival were stage, radiotherapy dose, stridor, retrosternal extension and fixation.
    Citation
    Primary malignant lymphoma of the thyroid: a clinicopathological analysis. 1992, 22 (5):929-33 Int J Radiat Oncol Biol Phys
    Journal
    International Journal of Radiation Oncology, Biology, Physics
    URI
    http://hdl.handle.net/10541/109618
    PubMed ID
    1555984
    Type
    Article
    Language
    en
    ISSN
    0360-3016
    Collections
    All Christie Publications

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