Show simple item record

Prognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood.

dc.contributor.authorDias, P
dc.contributor.authorKumar, Patricia
dc.contributor.authorMarsden, Henry B
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorKumar, Shant
dc.date.accessioned2010-08-11T17:47:34Z
dc.date.available2010-08-11T17:47:34Z
dc.date.issued1992
dc.identifier.citationPrognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood., 12 (4):1173-7 Anticancer Resen
dc.identifier.issn0250-7005
dc.identifier.pmid1503406
dc.identifier.urihttp://hdl.handle.net/10541/109521
dc.description.abstractA study of DNA content by flow cytometry revealed a significant difference between rhabdomyosarcomas, which were mainly non-diploid, and other sarcomas of children which were mainly diploid (p = 0.01). There was no association between DNA ploidy and survival or aggressive behaviour of the tumour as indicated for example by advanced clinical stage or unfavourable histology. While DNA ploidy correlated with age, it did not correlate with any other clinical characteristic. The apparent lack of prognostic value of DNA content may have been masked by some high CV values and overridden by the effect of chemotherapy which was the most significant variable in determining a patient's survival (p = 0.00005).
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectCancer Stagingen
dc.subject.meshAneuploidy
dc.subject.meshChild
dc.subject.meshDNA, Neoplasm
dc.subject.meshDiploidy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshRhabdomyosarcoma
dc.subject.meshSarcoma
dc.titlePrognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, United Kingdom.en
dc.identifier.journalAnticancer Researchen
html.description.abstractA study of DNA content by flow cytometry revealed a significant difference between rhabdomyosarcomas, which were mainly non-diploid, and other sarcomas of children which were mainly diploid (p = 0.01). There was no association between DNA ploidy and survival or aggressive behaviour of the tumour as indicated for example by advanced clinical stage or unfavourable histology. While DNA ploidy correlated with age, it did not correlate with any other clinical characteristic. The apparent lack of prognostic value of DNA content may have been masked by some high CV values and overridden by the effect of chemotherapy which was the most significant variable in determining a patient's survival (p = 0.00005).


This item appears in the following Collection(s)

Show simple item record