Changes in the extracellular matrix of the normal human breast during the menstrual cycle.
AffiliationCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
MetadataShow full item record
AbstractThe normal human mammary gland undergoes a well defined sequence of histological changes in both epithelial and stromal compartments during the menstrual cycle. Studies in vitro have suggested that the extracellular matrix surrounding the individual cells plays a central role in modulating a wide variety of cellular events, including proliferation, differentiation and gene expression. We therefore investigated the distribution of a number of extracellular matrix molecules in the normal breast during the menstrual cycle. By use of indirect immunofluorescence, with specific antibodies, we demonstrated that laminin, heparan sulphate proteoglycan, type IV collagen, type V collagen, chondroitin sulphate and fibronectin undergo changes in distribution during the menstrual cycle, whereas collagen types I, III, VI and VII remain unchanged. These changes were most marked in the basement membrane, sub-basement membrane zone and delimiting layer of fibroblasts surrounding the ductules where basement membrane markers such as laminin, heparan sulphate proteoglycan, and type IV and V collagens appear greatly reduced during the mid-cycle period (days 8 to 22). These results suggest that some extracellular matrix molecules may act as mediators in the hormonal control of the mammary gland, whereas others may have a predominantly structural role.
CitationChanges in the extracellular matrix of the normal human breast during the menstrual cycle. 1992, 268 (1):167-77 Cell Tissue Res
JournalCell and Tissue Research
- Distribution of integrins and the extracellular matrix proteins in the baboon endometrium during the menstrual cycle and early pregnancy.
- Authors: Fazleabas AT, Bell SC, Fleming S, Sun J, Lessey BA
- Issue date: 1997 Feb
- An immunohistochemical study of human endometrial extracellular matrix during the menstrual cycle and first trimester of pregnancy.
- Authors: Aplin JD, Charlton AK, Ayad S
- Issue date: 1988 Jul
- Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma.
- Authors: Ferguson JE, Schor AM, Howell A, Ferguson MW
- Issue date: 1990 Feb
- Composition of extracellular matrix and distribution of cell adhesion molecules in renal cell tumors.
- Authors: Droz D, Patey N, Paraf F, Chrétien Y, Gogusev J
- Issue date: 1994 Nov
- Immunohistochemical staining patterns of type VI collagen in the normal, hyperplastic, and neoplastic adult male breast.
- Authors: Magro G, Lanzafame S, Colombatti A
- Issue date: 1994 Apr