Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.
dc.contributor.author | Carrington, Bernadette M | |
dc.contributor.author | Thomas, N B | |
dc.contributor.author | Johnson, Richard J | |
dc.date.accessioned | 2010-08-11T16:26:03Z | |
dc.date.available | 2010-08-11T16:26:03Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures., 14 (1):13-7 Eur J Radiol | en |
dc.identifier.issn | 0720-048X | |
dc.identifier.pmid | 1563397 | |
dc.identifier.doi | 10.1016/0720-048X(92)90054-D | |
dc.identifier.uri | http://hdl.handle.net/10541/109500 | |
dc.description.abstract | A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%). | |
dc.language.iso | en | en |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Angiography | |
dc.subject.mesh | Catheterization | |
dc.subject.mesh | Celiac Artery | |
dc.subject.mesh | Contrast Media | |
dc.subject.mesh | Embolism | |
dc.subject.mesh | Equipment Design | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Interleukin-2 | |
dc.subject.mesh | Male | |
dc.subject.mesh | Melanoma | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Pain | |
dc.subject.mesh | Punctures | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Splenic Artery | |
dc.subject.mesh | Thrombosis | |
dc.title | Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures. | en |
dc.type | Article | en |
dc.contributor.department | Department of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K. | en |
dc.identifier.journal | European Journal of Radiology | en |
html.description.abstract | A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%). |