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dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorThomas, N Ben
dc.contributor.authorJohnson, Richard Jen
dc.date.accessioned2010-08-11T16:26:03Z
dc.date.available2010-08-11T16:26:03Z
dc.date.issued1992
dc.identifier.citationSelective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures., 14 (1):13-7 Eur J Radiolen
dc.identifier.issn0720-048X
dc.identifier.pmid1563397
dc.identifier.doi10.1016/0720-048X(92)90054-D
dc.identifier.urihttp://hdl.handle.net/10541/109500
dc.description.abstractA retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAngiography
dc.subject.meshCatheterization
dc.subject.meshCeliac Artery
dc.subject.meshContrast Media
dc.subject.meshEmbolism
dc.subject.meshEquipment Design
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshInterleukin-2
dc.subject.meshMale
dc.subject.meshMelanoma
dc.subject.meshMiddle Aged
dc.subject.meshPain
dc.subject.meshPunctures
dc.subject.meshRetrospective Studies
dc.subject.meshSplenic Artery
dc.subject.meshThrombosis
dc.titleSelective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Radiologyen
html.description.abstractA retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).


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