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    Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.

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    Authors
    Carrington, Bernadette M
    Thomas, N B
    Johnson, Richard J
    Affiliation
    Department of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
    Issue Date
    1992
    
    Metadata
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    Abstract
    A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).
    Citation
    Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures., 14 (1):13-7 Eur J Radiol
    Journal
    European Journal of Radiology
    URI
    http://hdl.handle.net/10541/109500
    DOI
    10.1016/0720-048X(92)90054-D
    PubMed ID
    1563397
    Type
    Article
    Language
    en
    ISSN
    0720-048X
    ae974a485f413a2113503eed53cd6c53
    10.1016/0720-048X(92)90054-D
    Scopus Count
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